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| Name | Class |
|---|---|
| University of Liege | OTHER |
| University of Namur | OTHER |
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Providing care for a disabled elderly may represent a risk for the health of the caregiver. The objective of the study is to assess the impact of caregiving in terms of clinical and biological markers in relation to disability and cognitive impairment.
The investigators hypothesize that an accumulation of stressful events related to care giving may induce a stress response to the caregiver. This stress response can be measured by biological markers (inflammation, transcription and immunity) and also by clinical markers (frailty, physical performance, nutrition). This stress response can be influenced by the subjective burden of the caregiver and by the severity of the disease of the care receiver (Activity of daily life capabilities, cognitive function, behavioral disturbance).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| caregivers | someone who takes care and lives with a disabled elderly |
| |
| controls | someone who lives with an healthy elderly |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Research questionnaires, blood sample | Other | assessment of health (frailty, nutrition, physical performance, depression, burden, sense of coherence, caregiver reaction) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Levels of biomarkers across groups | biomarkers of inflammation (cortisol, high sensitive C-Reactive Protein,Interleukin-6), immunity (TRECS, telomere length) and transcriptomics/epigenetics | at baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Relation between biomarkers, subjective burden and the care receiver situation | biomarkers of inflammation (cortisol, high sensitive C-Reactive Protein,Interleukin-6), immunity (TRECS, telomere length) and transcriptomics/epigenetics and their relations with the Zarit burden, the caregiver reaction assessment, the depression scale and the sense of coherence scale and with the situation of the care receiver ( Katz index, cognitive impairment, behavioral disturbance) |
| Measure | Description | Time Frame |
|---|---|---|
| Relation between biomarkers, subjective burden and the care receiver situation | biomarkers of inflammation (cortisol, high sensitive C-Reactive Protein,Interleukin-6), immunity (TRECS, telomere length) and transcriptomics/epigenetics and their relations with the Zarit burden, the caregiver reaction assessment, the depression scale and the sense of coherence scale and with the situation of the care receiver ( Katz index, cognitive impairment, behavioral disturbance) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| florence potier, MD | Contact | 0032/81 42 21 75 | florence.potier@uclouvain.be | |
| Marie de Saint-Hubert, MD, PhD | Contact | marie.desainthubert@uclouvain.be |
| Name | Affiliation | Role |
|---|---|---|
| Marie de Saint-Hubert, MD, PhD | CHUDinant-Godinne | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Dinant-Godinne | Recruiting | Mont-Godinne | Yvoir | 5530 | Belgium |
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood samples taken between 8 and 11 am. Blood parameters including cell counts and assays of acute phase proteins (C-reactive protein (CRP), albumin, pre-albumin) are determined according to the routine of the hospital.
PBMC are isolated by centrifugation in a Lympho-Ficoll gradient by the biobank of CHU Dinant Godinne.
Collected plasma is stored at -80 °C until analysis. The amounts of insulin-like growth factor-1 (IGF-1), interleukin-6 (IL-6) are essayed by enzyme-linked immunosorbent assay (ELISA).
PBMC are sent to Liege (GIGAI3) and Namur (URBC) for respectively ADN and ARN analyses.
ADN analyses concerned the immunity markers and ARN analyses concerned the transcriptomics and epigenetic markers.
The biobank of the CHU Dinant-Godinne meets the requirements of the quality book developed by the biobanks of Walonnie-Bruxelles (BWB).
| at baseline |
| at baseline |
| comparison of health events | Institutionalization, increase of formal home help services, hospitalisations | after 12 month |
| relation between biomarkers at baseline and functional decline | after 12 month |
| Levels of clinical markers across groups | frailty, physical performance, nutrition, depression | at baseline and after 12 month |
| relation between biomarkers at baseline and burden | after 12 month |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |