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High blood pressure in pregnancy affects around 10% of pregnancies, and is associated with serious adverse outcomes for both mother and baby. Treatment options for the management of high blood pressure in pregnancy are currently limited. Studies in non-pregnant individuals have shown that supplementation with dietary nitrate, using beetroot juice, can significantly lower blood pressure and improve blood flow. This study aims to investigate whether supplementation with dietary nitrate (via beetroot juice) can improve blood pressure regulation in pregnant women with chronic high blood pressure, and will also determine whether this can improve blood flow across the placenta.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dietary nitrate, beetroot juice | Experimental | Once daily 70mL dose of beetroot juice, containing 400mg inorganic nitrate, for 7 consecutive days. |
|
| Nitrate-depleted beetroot juice | Placebo Comparator | Once daily 70mL dose of beetroot juice, depleted of nitrate, for 7 consecutive days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beetroot juice | Dietary Supplement | 70mls daily for seven days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in clinic blood pressure (compared to baseline) between treatment and placebo groups | The outcome will be determined after 7 days treatment (compared to baseline) |
| Measure | Description | Time Frame |
|---|---|---|
| Recruitment rates | Across study (18 months) | |
| Uterine artery blood flow (compared to baseline) | The outcome will be determined after 7 days treatment (compared to baseline) | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maternal and Fetal Health Research Centre | Manchester | M13 9WL | United Kingdom |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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Dietary Nitrate
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| Nitrate-depleted beetroot juice |
| Dietary Supplement |
70mls daily for seven days |
|
| Umbilical artery blood flow (compared to baseline) |
| The outcome will be determined after 7 days treatment (compared to baseline) |
| Changes in plasma and salivary nitrate concentrations | The outcome will be determined after 7 days treatment (compared to baseline) |
| Changes in plasma and salivary nitrite concentrations | The outcome will be determined after 7 days treatment (compared to baseline) |