High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure

High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure

The primary objective of this pilot trial is to determine whether inpatients presenting to the Emergency Department (ED) with symptoms suggestive of Acute Heart Failure (AHF), who receive supplemental oxygen adjusted at either a high (SpO2 range ≥96%) or low (SpO2 range 90-92%) oxygen saturation level, leads to greater reduction in N-terminal-proBNP (NT-proBNP) at 72 hours.

Patients will be randomized to either a high (SpO2 range ≥96%) or low (SpO2 range 90-92%) oxygen after informed consent.

Inclusion Criteria:

• >40 years of age presenting to the ED with AHF
• objective finding of HF (BNP >400 pg/ml or Chest X-Ray with pulmonary congestion)
• plan to admit with primary diagnosis as HF
• must be able to be randomized within 16 hours of presenting to the ED
• provided written informed consent

Exclusion Criteria:

• on home oxygen
• known prior hypercapnic failure (PaCO2 >50 mmHg)
• asthma
• primary pulmonary hypertension,
• patients who require urgent positive pressure ventilation or intubation
• patients on >10 L/min oxygen