Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus

Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus During General Anesthesia Induction Period

By observing the difference of plasma homovanillic acid concentrations and brain electrical consciousness monitoring Narcotrend index, study the possible mechanism of influencing Etomidate induced myoclonus with Dexmedetomidine pretreatment during general anesthesia induction period.

Inclusion Criteria:

• Sign the informed consent
• American Society of Anesthesiologists (ASA)classification:class I~II;undergoing elective surgery patients
• Aged between 18 and 55, 49-67 kg weight
• Body Mass Index（BMI）： 20-30 kg/m2
• Did not use any analgesic or sedatives drugs within 24 h pre-operation

Exclusion Criteria:

• Recently patients undergoing sedative drugs and antidepressant treatment
• Serious vision, hearing impairment or other reasons can not communicate
• Serious neurological disease, pregnancy, diseases of the cardiovascular system；
• BMI is Less than the standard 80% or higher than the standard 120%