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Purpose: Clinical assessment (anthropometric) and paraclinical (biochemical and immunological by dosing serum insuline growth factors IGF1 and IGF2 and their receptors) of neonates with intrauterine growth restriction (IUGR) and the integration in a multidimensional statistical model .
Objectives:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IUGR: newborn with intrauterine growth restriction | Inclusion criteria:
| ||
| control: newborn without intrauterine growth restriction | Inclusion criteria: - matches newborn without intrauterine growth restriction in terms of gender and gestational age as IUGR group |
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| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of serum IGF2 | serum IGF2 | baseline |
| Evaluation of IGF2 receptors | serum IGF2 receptors | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Genetic evaluation | Number of subjects homozygous (A or G) and heterozygous (A/G) using forward primer: 5'- CTTGGACTTTGAGTCAAATTGG-3' and reverse primer: 5'-GGTCGTGCCAATTACATTTCA-3' genetic expression of IGF2 receptors. The groups will be evaluated in regards of polymorphism and allele frequencies. | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Population with IUGR from a 3rd level maternity from Nord-West of Romania
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Monica Gabriela Hășmășanu, MD | Contact | +40741985974 | popa.monica@umfcluj.ro | |
| Sorana D. Bolboacă, PhD Habil | Contact | +40750774506 | sbolboaca@umfcluj.ro |
| Name | Affiliation | Role |
|---|---|---|
| Gabriela Zaharie, PhD, MD | Iuliu Hațieganu Medicine and pharmacy University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neonatal-Ward, 1st Gynecology Clinic | Recruiting | Cluj-Napoca | Cluj | 400006 | Romania |
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| ID | Term |
|---|---|
| D005317 | Fetal Growth Retardation |
| ID | Term |
|---|---|
| D005315 | Fetal Diseases |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Clinical assessment |
Number of cases with respiratory distress, hyperbilirubinemia, early and late sepsis, hypoglicemia, necrozant enterocolitis or other co-morbidities. |
| baseline |
| Cardiac morphological and functional evaluation | Eco cardiac measurements will be performed to all participants and the morphological and functional data will be recorded baseline for all participant (IUGR and controls). As results number of subjects with cardiac morphological and functional evaluation will be according with subjects included in the study and those subjects with cardiac modification or those from case group will be evaluated dynamically. | baseline and follow-up (1 month and/or 6 months) |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006130 | Growth Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |