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This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.
Aerobic exercise training is well known to improve endothelium dependent vasodilatation in the microcirculation. However, the impact of exercise frequency on this response in patients with coronary artery disease remains unclear.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 2x/wk | This group will be consisted of patients that will perform exercise two times a week. |
| |
| 3x/wk | This group will be consisted of patients that will perform exercise three times a week. |
| |
| Control | This group will not perform exercise. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Patients included in the study will be enrolled in a cardiac rehabilitation program, in an independent manner of the study protocols. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Skin microvascular blood flow | Measured through a Laser Speckle Contrast Imaging equipment | Change from baseline in skin microvascular blood flow at 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in peak oxygen consumption | Measured at a maximal graded exercise test | Change from baseline in peak oxygen consumption at 6 months |
| Change in weight | Measured with a calibrated digital scale |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated in the hospital in which the exercise will be performed.
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| Name | Affiliation | Role |
|---|---|---|
| Eduardo V Tibiriçá, PhD | Instituto Fernandes Figueira | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto Nacional de Cardiologia | Rio de Janeiro | Rio de Janeiro | 21040-900 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24172594 | Background | Souza EG, De Lorenzo A, Huguenin G, Oliveira GM, Tibirica E. Impairment of systemic microvascular endothelial and smooth muscle function in individuals with early-onset coronary artery disease: studies with laser speckle contrast imaging. Coron Artery Dis. 2014 Jan;25(1):23-8. doi: 10.1097/MCA.0000000000000055. | |
| 22326551 | Background |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Blood samples for nitrite/nitrate quantification.
| Sedentarism | Behavioral | Participants will remain sedentary. |
|
| Change from baseline in weight at 6 months |
| Cordovil I, Huguenin G, Rosa G, Bello A, Kohler O, de Moraes R, Tibirica E. Evaluation of systemic microvascular endothelial function using laser speckle contrast imaging. Microvasc Res. 2012 May;83(3):376-9. doi: 10.1016/j.mvr.2012.01.004. Epub 2012 Jan 31. |
| 27333938 | Derived | Borges JP, Mediano MF, Farinatti P, Coelho MP, Nascimento PM, Lopes GO, Kopiler DA, Tibirica E. The Effects of Unsupervised Home-based Exercise Upon Functional Capacity After 6 Months of Discharge From Cardiac Rehabilitation: A Retrospective Observational Study. J Phys Act Health. 2016 Nov;13(11):1230-1235. doi: 10.1123/jpah.2016-0058. Epub 2016 Aug 24. |