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The purpose of this study is to determine whether autologous platelet rich plasma (APRP)is effective in reducing allogeneic blood transfusions during aortic surgery using deep hypothermic circulatory arrest.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| APRP group | Experimental | APRP group is performed autologous platelet-rich plasma harvest technique before administration of heparin to the patient,the red blood cell(RBC) component is retransfused to the patient when the RBC transfusion protocol is reached,and the autologous platelet-rich plasma is transfused to the patient immediately after heparin is neutralized with protamine. |
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| control group | No Intervention | APRP group receive no autologous platelet-rich plasma harvest technique. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Autologous Platelet-Rich Plasma Harvest Technique | Device | 15 to 20 mL/kg of whole blood is collected before the administration of heparin from a large-bore central venous access,and is separated into red blood cells component and autologous platelet-rich plasma component by an autologous transfusion system(Sorin Group Electa Essential; Sorin Group Italia, Milan, Italy). |
| Measure | Description | Time Frame |
|---|---|---|
| total perioperative allogenic transfusions of platelet and fresh frozen plasma | on the 7th day postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative blood loss | on the 7th day postoperatively | |
| rate of reexploration for bleeding | on the 7th day postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hongwen Ji, MD | Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC | Study Chair |
| Yongyuan Wang | Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC | Beijing | Beijing Municipality | 100037 | China |
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