Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke

Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke

Evaluating an innovative molecular imaging technique to visualize inflammation of the atherosclerotic plaque in patients with a recent ischemic stroke (<15 days) with carotid stenosis> 50%, by performing a Positron emission tomography-computed tomography (PET-CT) with PBR06 18F, a tracer for Translocator protein (TPSO).

More than one third of cerebral ischemic events are related to an atheromatous plaque. Inflammation, through a key player, the macrophage, is associated with increased metabolic activity of atherosclerotic plaque and its possible rupture. Inflammation within the plate is thus a marker of instability. These data underscore the importance of a prospective evaluation of inflammation with specific imaging with PET tracers inflammation.

Inclusion Criteria:

• Man with transient ischemic attack or recent ischemic stroke (<15j) in the carotid territory, confirmed by MRI
• Man with carotid stenosis> 50% on the side of stroke
• Male candidate for carotid endarterectomy
• Subject affiliated or beneficiary of a social security scheme
• Informed written consent

Exclusion Criteria:

• Women
• Chronic inflammatory disease in progress (cancer, vasculitis, ...)
• Patient with infection within 7 days
• A person placed under judicial protection, guardianship
• Incapable of giving consent
• Low affinity binder for TSPO