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The backgroud of this study was not well discussed.
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Volume controlled ventilation(VCV) is a most common used ventilation mode during general anesthesia. But VCV can cause high airway peak pressure when patient under steep Trendelenberg position with pneumoperitoneum. Autoflow-VCV can reduce airway peak pressure and improve dynamic compliance. We will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied VCV and autoflow-VCV during RALP.
Robot assisted laparoscopic radical prostatectomy(RALP) has been used to treatment of prostate cancer since 2001. RALP offers some advantage such as reduced blood loss, sparing nerves, less postoperative pain. However, RALP require steep Trendelenberg position with pneumoperitoneum. It can cause increased airway peak pressure and unwanted hemodynamic effect under conventional volume controlled ventilation(VCV). Autoflow-VCV use decelerating flow, can reduce airway peak pressure and improve dynamic compliance.
We will compare parameters(arterial blood gas analysis, airway compliance, etc) when each group applied VCV and autoflow-VCV during RALP.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| volume controlled ventilation | Experimental | Randomized 23 patients will be applied VCV during RALP. |
|
| autoflow-volume controlled ventilation | Active Comparator | Randomized 23 patients will be applied autoflow-VCV during RALP. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| volume controlled ventilation | Device | After induction of anesthesia and intubation, patients will be applied VCV by Zeus®(Dräger, Germany). - Tidal volume : 8ml/kg(ieal body weight), inspiration:expiration ratio = 1:2, FiO2 = 0.5, fresh gas flow = 3L/min respiratory rate(RR) : 12/min. After position, RR can changed 2 times each per 5 minutes to maintain end tidal CO2 around 35. Positive end expiratory pressure will not used. |
| Measure | Description | Time Frame |
|---|---|---|
| Airway pressure | Airway pressure will be measured under specified ventilation mode. | 4hours |
| Measure | Description | Time Frame |
|---|---|---|
| Vital sign | Vital sign will be measured under specified ventilation mode. | 4hours |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial blood gas analysis | Arterial blood gas analysis will be measured under specified ventilation mode. | 4hours |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hye-Won Shin, MD, PhD | Department of anesthesiology and pain medicine, Korea University Anam Hospital | Study Director |
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| ID | Term |
|---|---|
| D011471 | Prostatic Neoplasms |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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|
| autoflow-volume controlled ventilation | Device | After induction of anesthesia and intubation, patients will be applied autoflow- VCV by Zeus®(Dräger, Germany). - Tidal volume : 8ml/kg(ideal body weight), inspiration:expiration ratio = 1:2, FiO2 = 0.5, fresh gas flow = 3L/min respiratory rate(RR) : 12/min. After position, RR can changed 2 times each per 5 minutes to maintain end tidal CO2 around 35. Positive end expiratory pressure will not used. |
|
| D005832 |
| Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |