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Hypothesis:
Stimulation of the SPG at low frequencies (20 Hz)is believed to cause a physiological parasympathetic upregulation which increases VMCA, concentration and cephalic vessel diameter.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SPG neurostimulation | Active Comparator | SPG neurostimulation of frequency 20 Hz |
|
| Control | Sham Comparator | Sham neurostimulation of amplitude=0 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neurostimulation | Device | Neurostimulation of sphenopalatine ganglion (SPG) of 20 Hz |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of mean blood velocity of middle cerebral artery (VMCA) using transcranial Doppler upon low frequency SPG stimulation | 0-90 min |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish Headache Center | Copenhagen | Glostrup | 2600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32321288 | Derived | Guo S, Falkenberg K, Schytz HW, Caparso A, Jensen RH, Ashina M. Low frequency activation of the sphenopalatine ganglion does not induce migraine-like attacks in migraine patients. Cephalalgia. 2020 Aug;40(9):966-977. doi: 10.1177/0333102420921156. Epub 2020 Apr 22. |
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| Sham stimulation | Device | Sham stimulation of sphenopalatine ganglion (SPG) with amplitude=0 |
|