Effect of Dexamethasone on the Action of Sugammadex

This study aims to investigate the possible clinical effect of dexamethasone on the action of sugammadex when it is administered to reverse deep neuromuscular blockade caused by rocuronium in laparoscopic cholecystectomies.

Inclusion Criteria:

• patients aged 18-70 years
• laparoscopic cholecystectomy
• operation < 3 hours

Exclusion Criteria:

• age <18 or >70 years old
• ASA physical status >3
• central nervous system diseases
• severe psychiatric disorders under treatment
• cognitive dysfunction
• known or suspected allergy to the administered drugs
• operations > 3 hours
• surgical intraoperative complications-open cholecystectomy
• severe renal or liver disease
• diabetes melitus
• immunosuppressed patients
• chronic immunosuppresant therapy (corticosteroids or other drugs)
• all contraindications to corticosteroids administration
• patiens on chronic use of opioids