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| Name | Class |
|---|---|
| University Hospital, Estaing | OTHER |
The study is intended to elucidate the pulmonary effects of Intrapulmonary Percussive Ventilation (IPV) with VDR4 ventilator of patients with ARDS, using computed tomography (CT).
Prospective clinical study in ICU of ventilated patients with ARDS. The morphologic pulmonary effects of IPV with VDR4 are not known to the investigators' knowledge.
The main aim is to quantify recruited, normally aerated and overinflated parts of the lungs after a 1 hour treatment with IPV.
Patients with ARDS (focal and non focal) consecutively admitted to the investigators' ICU are enrolled after informed consent.
Patients are intubated and ventilated with Servo-I (GE) and ventilation is optimized according to ARDS-network recommandations.
A first thoracic CT-scan is performed with ICU ventilator and then the patient is ventilated with VDR4 during 1 hour.
A second thoracic CT-scan is then performed and the patient re-ventilated with ICU ventilator.
Arterial blood gases and hemodynamic parameters are recorded during experiments.
CT-scan are analysed and compared for normally aerated, overinflated and recruited lung parenchyma. Regions are determined thanks to their Hounsfield units (HU).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ARDS patients | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VDR4 ventilator (Intrapulmonary Percussive Ventilation) | Device |
| ||
| CT scan |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline (H0) in volume of overinflated lung at H1 | at Hour 0(just before Intrapulmonary Percussive Ventilation) and Hour 1(just after Intrapulmonary Percussive Ventilation) |
| Measure | Description | Time Frame |
|---|---|---|
| Volume of normally aerated lung | at Hour 0 (just before Intrapulmonary Percussive Ventilation ) and Hour 1 (just after Intrapulmonary Percussive Ventilation) | |
| Volume of recruited lung | at day 1 (between H0 and H1) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Patrick LACARIN | Contact | 04 73 75 11 95 | placarin@chu-clermontferrand.fr |
| Name | Affiliation | Role |
|---|---|---|
| Jean-Michel CONSTANTIN | University Hospital, Clermont-Ferrand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Clermont-Ferrand | Clermont-Ferrand | 63003 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29325586 | Derived | Godet T, Jabaudon M, Blondonnet R, Tremblay A, Audard J, Rieu B, Pereira B, Garcier JM, Futier E, Constantin JM. High frequency percussive ventilation increases alveolar recruitment in early acute respiratory distress syndrome: an experimental, physiological and CT scan study. Crit Care. 2018 Jan 11;22(1):3. doi: 10.1186/s13054-017-1924-6. |
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| Device |
|
| Servo-i | Device |
|
| - Intubation | Device |
|
| Ventilation ( with an ICU conventional ventilator) | Device |
|
| Heart rate | at day 1 ((every 10 min between H0 and H1) |
| Blood pressure | at day 1 (every 10 min between H0 and H1) |
| Arterial blood gaz | at day 1 ((every 10 min between H0 and H1) |
| Evolution of catecholamine doses (µg/Kg/min) | at day 1 (every 10 min between H0 and H1) |
| ID | Term |
|---|---|
| D014057 | Tomography, X-Ray Computed |
| D007440 | Intubation |
| ID | Term |
|---|---|
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D014054 | Tomography |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
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