Could Pre-operative Rectal Misoprostol Reduce Intra-operative Blood Loss During Ceserean Section?

Randomized, Placebo-controlled Double Blind Study of Preoperative Misorostol for Reduction of Intraoperative Bleeding in Women Delivered by Ceserean Section

• Misoprostol reduces the uterine bleeding after cesarean delivery without harmful effects on either mother or baby.
• The aim of the this study is to address if there is any benefits 'regarding the intra-operative blood loss' from preoperative rectal administration of 400 mic of Misoprostol in addition to the routinely administrated 10 units of oxytocin

Research question:

In women undergoing elective ceserean section, is preoperative 400 mic Misoprostol reduce intra-operative blood loss?

Research hypothesis:

pre-operative Misoprostol doesn't reduce intraoperative blood loss in women undergoing ceserean section

Inclusion Criteria:

• 38-41 weeks of amenorrhea
• scheduled for elective lower segment cesarean section

Exclusion Criteria:

• confirmed intrauterine fetal death
• more than previous 2 ceserean sections
• multiple pregnancy
• antepartum haemorrhage
• self-reported maternal heart disease
• current diagnosis of severe malaria or acute bacterial infection