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| Name | Class |
|---|---|
| Helen Keller International | OTHER |
| BRAC University | OTHER |
| University of Giessen | OTHER |
| German Federal Ministry of Education and Research |
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The aim of this study is to evaluate the potential of reducing young child undernutrition in low-income countries through an integrated program that trains women's groups in agriculture, nutrition, child care and hygiene.
An estimated 165 million children worldwide suffer from chronic undernutrition which leads to compromised physical and cognitive development and prevents them from reaching their full potential. Nutrition-sensitive agricultural interventions that aim to increase dietary diversity, empower women and include an educational behaviour change component focused on nutrition and hygiene are a promising and sustainable approach to addressing undernutrition. However, evidence on the impact of such interventions is still scarce due to a lack of rigorous long-term evaluations.
This study will test the hypothesis that integrated agriculture, nutrition and hygiene interventions can reduce undernutrition when children benefit in their crucial first 1000 days. The investigators will conduct an impact evaluation of Helen Keller International's Homestead Food Production program in Bangladesh that trains women's groups in vegetable and fruit gardening, poultry rearing, hygiene, child care and nutrition. Furthermore, the investigators will assess the program impact pathway to discern how any impact is achieved (through improved food production, income, food security, health service use, female empowerment, feeding and hygiene practices).
The study design is a cluster-randomized controlled field trial in two sub-districts of Habiganj District, Sylhet Division, Bangladesh, including 2700 young women in 96 settlements. After the baseline survey in 2015, settlements will be randomized into 48 intervention and 48 control settlements. Women in the intervention settlements will receive training and support in Homestead Food Production during the following four years. A surveillance system will collect data on pregnancies, births, child development, nutrition and infections as well as pathway indicators. In 2019, the investigators will conduct the endline survey to assess the nutritional status of the 2700 women and their then approximately 1500 children below 3 years of age and compare between intervention and control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Homestead Food Production | Experimental | Enrolled in Homestead Food Production program from 2015 to 2019, 48 clusters, approx. 1350 women and 750 children |
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| Control | No Intervention | (Health system strengthening in the study area), 48 clusters, approx. 1350 women and 750 children |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Homestead Food Production program | Behavioral | Training and support for vegetable gardening and poultry rearing, and education on young child nutrition, hygiene and health topics, in women's groups, as designed by the international non-governmental organization (NGO) Helen Keller International (HKI). |
| Measure | Description | Time Frame |
|---|---|---|
| Linear growth in children below 3 years of age | Length/height-for-age Z-score | Measured 50 months after randomization (endline survey 2019) |
| Measure | Description | Time Frame |
|---|---|---|
| Linear growth in children aged 6-30 months | Length/height-for-age Z-score | Measured 50 months after randomization |
| Intrauterine growth retardation: length | Length-for-gestational-age |
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Inclusion Criteria:
For settlements:
For women:
For children:
Exclusion Criteria:
For women:
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| Name | Affiliation | Role |
|---|---|---|
| Sabine Gabrysch, MD MSc PhD | Heidelberg University | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42086300 | Derived | Sparling TM, Cornejo C, Offner C, Mayer A, Waid JL, Kadiyala S, Gabrysch S. Nutrition-sensitive agriculture programme impacts women's mental health via food security in rural Bangladesh. BMJ Glob Health. 2026 May 5;11(5):e020509. doi: 10.1136/bmjgh-2025-020509. | |
| 40387380 | Derived | Wendt AS, Waid JL, Muller-Hauser AA, Lambrecht NJ, Huda TMN, Kyei NNA, Gabrysch S. Impacts of a Homestead Food Production Intervention on Anaemia and Micronutrient Deficiencies Among Women and Children in Rural Bangladesh: A Cluster-Randomized Controlled Trial. Matern Child Nutr. 2025 Oct;21(4):e70043. doi: 10.1111/mcn.70043. Epub 2025 May 19. |
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| ID | Term |
|---|---|
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000383 | Agriculture |
| D015596 | Nutrition Assessment |
| ID | Term |
|---|---|
| D013676 | Technology, Industry, and Agriculture |
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
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| OTHER_GOV |
| Department for International Development, United Kingdom | OTHER_GOV |
| International Centre for Diarrhoeal Disease Research, Bangladesh | OTHER |
| German Research Foundation | OTHER |
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| Measured within 3 days of birth, 15-57 months after randomization |
| Intrauterine growth retardation: small-for-gestational age | Weight-for-gestational-age adjusted for time since birth | Measured within 3 days of birth, 15-57 months after randomization |
| Intrauterine growth retardation: head size | Head circumference-for-gestational-age | Measured within 3 days of birth, 15-57 months after randomization |
| Wasting in children below 3 years of age | Weight-for-length/height Z-score | Measured 50 months after randomization |
| Head circumference in children below 3 years of age | Head circumference-for-age Z-score | Measured 50 months after randomization |
| Underweight in women | Body Mass Index (BMI, non-pregnant women), mid-upper-arm circumference (MUAC, pregnant women) | Measured 50 months after randomization |
| Gestational weight gain | Gestational weight gain Z-score | Measured every 2 months during pregnancy, 6-57 months after randomization |
| Anemia in women and children below 3 years of age | Hemoglobin concentration | Measured 50 months after randomization |
| Micronutrients: Vitamin A deficiency in women and in children below 3 years of age | Retinol-binding protein, corrected for inflammation (CRP, AGP) | Measured 50 months after randomization |
| Micronutrients: Iron deficiency in women and in children below 3 years of age | Ferritin and soluble transferrin receptor, corrected for inflammation (CRP, AGP) | Measured 50 months after randomization |
| Micronutrients: Zinc deficiency in women and in children below 3 years of age | Serum zinc, corrected for inflammation (CRP, AGP) | Measured 50 months after randomization |
| Early child development (adapted WHO milestones) | Gross and fine motor, cognitive, personal-social and communication skills | Measured at appropriate ages for milestones, 6-50 months after randomization |
| Diarrhea in children below 3 years of age | Period and point prevalence of diarrhea | Measured every 2 months, 6-50 months after randomization |
| Acute respiratory infection in children below 3 years of age | Period prevalence of acute respiratory infection | Measured every 2 months, 6-50 months after randomization |
| Enteropathy in children below 18 months of age | Biomarkers: faecal myeloperoxidase, faecal α1-antitrypsin, faecal neopterin, serum C-reactive protein, serum α-1-acid glycoprotein | Measured 36 and 50 months after randomization |
| Dietary adequacy in women and children below 3 years of age | Mean probability of adequate micronutrient intake (MPA) | Measured every 2 months, 6-50 months after randomization |
| Dietary diversity in women and children below 3 years of age | Individual dietary diversity score, breastfeeding behaviors | Measured every 2 months, 6-50 months after randomization |
| Fecal contamination of complementary food for children 6-18 months of age | Log-transformed counts of total coliforms and E. coli in complementary food samples | Measured 36 months after randomization |
| Food hygiene behaviour in mothers of children aged 6-18 months | Hygiene score from structured observation of mothers | Measured 36 months after randomization |
| 37983985 | Derived | Sobhan S, Muller-Hauser AA, Gon G, Nurul Huda TM, Waid JL, Wendt AS, Rahman M, Gabrysch S. Effect of a behaviour change intervention on household food hygiene practices in rural Bangladesh: A cluster-randomised controlled trial. Int J Hyg Environ Health. 2024 Jan;255:114291. doi: 10.1016/j.ijheh.2023.114291. Epub 2023 Nov 18. |
| 37871747 | Derived | Waid JL, Wendt AS, Kader A, Sobhan S, Gabrysch S. Impact of a Homestead Food Production Program on Dietary Diversity: Seasonal and Annual Results from the Cluster-Randomized FAARM Trial in Sylhet, Bangladesh. J Nutr. 2024 Jan;154(1):191-201. doi: 10.1016/j.tjnut.2023.10.014. Epub 2023 Oct 21. |
| 37783459 | Derived | Muller-Hauser AA, Huda TMN, Sobhan S, Lambrecht NJ, Waid JL, Wendt AS, Ali S, Rahman M, Gabrysch S. Effect of a Homestead Food Production and Food Hygiene Intervention on Biomarkers of Environmental Enteric Dysfunction in Children Younger Than 24 Months in Rural Bangladesh: A Cluster-Randomized Controlled Trial. Am J Trop Med Hyg. 2023 Oct 2;109(5):1166-1176. doi: 10.4269/ajtmh.23-0153. Print 2023 Nov 1. |
| 37580032 | Derived | Lambrecht NJ, Muller-Hauser AA, Sobhan S, Schmidt WP, Huda TMN, Waid JL, Wendt AS, Kader A, Gabrysch S. Effect of a Homestead Food Production Program on the Prevalence of Diarrhea and Acute Respiratory Infection in Children in Sylhet, Bangladesh: A Cluster-Randomized Controlled Trial. Am J Trop Med Hyg. 2023 Aug 14;109(4):945-956. doi: 10.4269/ajtmh.23-0152. Print 2023 Oct 4. |
| 35045859 | Derived | Dupuis S, Hennink M, Wendt AS, Waid JL, Kalam MA, Gabrysch S, Sinharoy SS. Women's empowerment through homestead food production in rural Bangladesh. BMC Public Health. 2022 Jan 19;22(1):134. doi: 10.1186/s12889-022-12524-2. |
| 31620671 | Derived | Wendt AS, Waid JL, Gabrysch S. Dietary Factors Moderate the Relation between Groundwater Iron and Anemia in Women and Children in Rural Bangladesh. Curr Dev Nutr. 2019 Aug 6;3(10):nzz093. doi: 10.1093/cdn/nzz093. eCollection 2019 Oct. |
| 31278109 | Derived | Wendt AS, Sparling TM, Waid JL, Mueller AA, Gabrysch S. Food and Agricultural Approaches to Reducing Malnutrition (FAARM): protocol for a cluster-randomised controlled trial to evaluate the impact of a Homestead Food Production programme on undernutrition in rural Bangladesh. BMJ Open. 2019 Jul 4;9(7):e031037. doi: 10.1136/bmjopen-2019-031037. |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
| D004778 | Environment and Public Health |