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Purpose:
Fluid responsiveness in a context of circulatory failure can be predicted by different way. Dynamic criteria such as pulse pressure variation, stroke volume variation during an end-expiratory occlusion maneuver or a passive leg raising have been reported to predict fluid responsiveness. Only aortic velocity peak variation measured with transthoracic echocardiography during mechanical ventilation has been reported to predict fluid responsiveness in children. Besides some physician use a maneuver of abdominal compression to predict fluid responsiveness in children with circulatory failure. This strategy has never been formally evaluated.
The investigators will study the diagnosis accuracy of the stroke volume variation induced by an abdominal compression to predict stroke volume variation after 10 ml/kg fluid load in children with circulatory failure.
Thirty-eight pediatric patients under eight years old in circulatory failure, for whom the attending physician has decided a fluid load will be included. Hemodynamic parameters: arterial pressure, heart rate, stroke volume measured with echocardiography; will be recorded. This data collection will be performed before, after abdominal compression and after a fluid load of 10 ml/kg.
Patients will be aposteriori sorted in two groups: Fluid responders and Fluid non-responders. Fluid responders are defined as patients that show an increase greater than 15 % in stroke volume. The diagnosis ability of the Stroke volume variation after an abdominal compression to predict fluid responsiveness will be investigate and receiving operative characteristic (ROC) curve will be built. The correlation between the variation of stroke volume during abdominal compression and during the fluid load will be studied. Other parameters such as arterial pressure and heart rate will also be investigated.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observational study. No special intervention will be made | Other | Data will be recorded in a context of fluid load in a context of circulatory failure. Stroke volume will be monitored, before, after an abdominal compression and after a fluid load. |
| Measure | Description | Time Frame |
|---|---|---|
| Ability of the stroke volume variation after abdominal compression to predict fluid responsiveness | Stroke volume will be measured before and after a calibrated abdominal compression and after a fluid load. Patient will then be sorted in two groups. Responders defined as patient that show an increase in stroke volume after a 10ml/kg fluid load and Fluid non responders, defined as patient that show an increase of less than 15 % in stroke volume. The ROC curve will investigate the ability of stroke volume variation after abdominal compression to predict fluid responsiveness. | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Ability of the pulse pressure variation after abdominal compression to predict fluid responsiveness | 30 minutes | |
| Ability of the heart rate variation after abdominal compression to predict fluid responsiveness | 30 minutes |
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Inclusion Criteria:
Treatment including vasopressor or inotrope
OR macrocirculatory failure
WITH signs of microcirculatory failure
Exclusion Criteria:
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Patient hospitalized in the intensive care unit of the hospital " feme mère enfant " or the cardiologic hospital of BRON who suffer from circulatory failure and for whom the attending physiscian has decided to administer a 10 ml/kg cristalloïd infusion.
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Luc Fellahi, MD, PhD | Hôpital Louis Pradel, Hospice Civil de Lyon | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Intensive care and anesthesiology department, Hôpital Louis Pradel. | Lyon | France | ||||
| Pediatric Intensive care, Hôpital Femme Mère Enfant |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30442260 | Derived | Jacquet-Lagreze M, Tiberghien N, Evain JN, Hanna N, Courtil-Teyssedre S, Lilot M, Baudin F, Chardonnal L, Bompard D, Koffel C, Portefaix A, Javouhey E, Fellahi JL. Diagnostic accuracy of a calibrated abdominal compression to predict fluid responsiveness in children. Br J Anaesth. 2018 Dec;121(6):1323-1331. doi: 10.1016/j.bja.2018.06.030. Epub 2018 Sep 6. |
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| ID | Term |
|---|---|
| D012769 | Shock |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Correlation between stroke volume variation, heart rate variation, pulse pressure variation between the abdominal compression and the fluid load | 30 minutes |
| Lyon |
| France |