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A circulating tumor cell (CTC) count is an established prognostic factor in some malignancies such as metastatic breast cancer. However, the value of CTC in diagnosis and outcome prediction of metastatic nasopharyngeal carcinoma (mNPC) patients is not unknown. Through the observational prospective clinical trial, sensitivity, specificity, positive and negative predictive values of CTC in diagnosis of mNPC patients will be gained. Further, the value of CTC in outcome prediction of mNPC patients will be uncovered.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study Group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| the number of circulating tumor cells | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival rate | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of positives that are correctly identified as such | number of true positives divided by (number of true positives plus number of false negatives) | 3 years |
| The proportion of negatives that are correctly identified as such |
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Inclusion Criteria:
Exclusion Criteria:
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NPC patients with distant metastasis
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| Name | Affiliation | Role |
|---|---|---|
| Ming-Yuan Chen, MD, PhD | Sun Yat-Sen University Cancer Center | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24888818 | Result | Smerage JB, Barlow WE, Hortobagyi GN, Winer EP, Leyland-Jones B, Srkalovic G, Tejwani S, Schott AF, O'Rourke MA, Lew DL, Doyle GV, Gralow JR, Livingston RB, Hayes DF. Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500. J Clin Oncol. 2014 Nov 1;32(31):3483-9. doi: 10.1200/JCO.2014.56.2561. Epub 2014 Jun 2. | |
| 25474037 |
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| ID | Term |
|---|---|
| D009303 | Nasopharyngeal Neoplasms |
| D000077274 | Nasopharyngeal Carcinoma |
| D009360 | Neoplastic Cells, Circulating |
| ID | Term |
|---|---|
| D010610 | Pharyngeal Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
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The blood after separation and purification along with or without CTC.
number of true negatives divided by (number of true negatives plus number of false positives)
| 3 years |
| The proportions of positive results in statistics and diagnostic tests that are true positive results. | number of true positives divided by number of positive calls | 3 years |
| The proportions of negative results in statistics and diagnostic tests that are true negative results. | number of true negatives divided by number of negative calls | 3 years |
| Zhang Z, Shiratsuchi H, Lin J, Chen G, Reddy RM, Azizi E, Fouladdel S, Chang AC, Lin L, Jiang H, Waghray M, Luker G, Simeone DM, Wicha MS, Beer DG, Ramnath N, Nagrath S. Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model. Oncotarget. 2014 Dec 15;5(23):12383-97. doi: 10.18632/oncotarget.2592. |
| 15735118 | Result | Cristofanilli M, Hayes DF, Budd GT, Ellis MJ, Stopeck A, Reuben JM, Doyle GV, Matera J, Allard WJ, Miller MC, Fritsche HA, Hortobagyi GN, Terstappen LW. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol. 2005 Mar 1;23(7):1420-30. doi: 10.1200/JCO.2005.08.140. |
| D009369 | Neoplasms |
| D009302 | Nasopharyngeal Diseases |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009362 | Neoplasm Metastasis |
| D009385 | Neoplastic Processes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |