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Recruitment issues
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During this study the investigators will 1) collect measures of social cognition and social functioning in adolescents and young adults who are experiencing early symptoms of a major mental disorder; and 2) evaluate the predictive value and utility of a new role functioning assessment measure for individuals experiencing changes in their lives after an index episode of mental illness. This will happen in the context of providing treatment-as-usual to individuals who arrive seeking help with the early phases of mental illness.
The early symptoms of major mental disorders, such as bipolar disorder and schizophrenia, can be non-specific, attenuated, or intermittent. These symptoms nevertheless frequently interfere with an individuals' ability to effectively carry-out multiple aspects of their everyday lives, including social, vocational, and educational functioning. Functional changes may in fact occur before individual symptoms reach the threshold for clinical significance. Relying solely on the emergence of early symptoms of psychopathology can delay treatment or lead to the improper selection of treatments that are not effective. Therefore, measuring changes in real-world functioning that correlate with or predate symptoms may be a useful tool for developing an effective treatment plan.
While psychopharmacology and psychotherapy can improve some symptoms of severe mental illness, much less is known about the mechanisms for improving impairments in social cognition. Importantly social cognition affects not just social functioning, but many critical aspects of real-world functioning. Thus, advancing our understanding of how social cognition and real-world functioning change over time, and their association to changing clinical symptoms, will help improve our understanding of early mental illness, and should inform patient care in new ways. Currently, there are only a limited number of tools available for assessing aspects of real-world functioning as they connect to social cognition. Therefore, the overarching goal of the present study is to conduct a pilot study to develop a new tool that measures functioning and evaluate the relationship between this new tool and measures of social cognition and symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment seeking patients | Patients between 18 and 26 who arrive seeing treatment for new-onset mental health symptoms. They will receive treatment as usual, while being assessed overt he course of one year for changes in role functioning. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pharmacotherapy | Drug | Participants may receive pharmacotherapy in the course of treatment-as-usual. This observational study does not influence the type of treatment administered. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlates between Role Functioning Rating Scale (RFRS), clinical symptoms, and social cognition | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| PONS | Profile of non-verbal sensitivity | 1 year |
| TASIT | The Awareness of Social Inference Test | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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Young adults with emerging psychopathology. Therefore, all subjects we recruit will be in the age range spanning adolescence and young adulthood, who come to a clinic seeking psychiatric care.
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| Name | Affiliation | Role |
|---|---|---|
| Will J Cronenwett, MD | Northwestern University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northwestern University | Chicago | Illinois | 60611 | United States |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D011618 | Psychotic Disorders |
| D001714 | Bipolar Disorder |
| D001523 | Mental Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
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| ID | Term |
|---|---|
| D004358 | Drug Therapy |
| D001521 | Behavior Therapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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| Behavioral treatment | Behavioral | Participants may receive behavioral treatment in the course of treatment-as-usual. This observational study does not influence the type of treatment administered. |
|
| BLERT | Bell-Lysaker Emotion Recognition Task | 1 year |
| SFS | Social Functioning Scale | 1 year |
| UPSA | UCSD Performance-Based Skills Assessment | 1 year |
| EPT | Emotional Perspective-Taking Task | 1 year |
| FAP | Facial Affect Perception Task | 1 year |
| Informant SLOF | Informant Specific Levels of Functioning Scale; administered to an informant of a participant | 1 year |
| SLOF | Specific Levels of Functioning Scale | 1 year |
| RFS | Role Functioning Scale | 1 year |
| ERS | Emotional Reactivity Scale | 1 year |
| ASSIST | Alcohol, Smoking and Substance Involvement Screening Test | 1 year |