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| ID | Type | Description | Link |
|---|---|---|---|
| BAPT201534 | Registry Identifier | BAPT201534 |
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| Name | Class |
|---|---|
| Firestone Institute for Respiratory Health | OTHER |
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The purpose of this study is to establish the methodology of bronchial provocation tests with house dust mites in China, and to evaluate its safety and effects on upper and lower airways inflammation.
After screening,each participant undergo baseline lung function test,airway inflammation evaluation (blood and sputum eosinophils count,interleukin-13 (IL-13),FeNO)and airway responsiveness tests(methacholine bronchial provocation,nasal histamine provocation).
On the second day,the participant undergo bronchial house dust mites challenge tests.
On the third day,the participant undergo the lung function test,airway inflammation evaluation (blood and sputum eosinophils count,IL-13,FeNO)and airway responsiveness tests(methacholine bronchial provocation,nasal histamine provocation).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| allergic asthma | Experimental | asthma patients that sensitive to house dust mites. |
|
| normal controls | Experimental | normal controls with or without sensitive to house dust mites. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| house dust mites | Other | house dust mites(two-fold increasing concentration of house dust mite (HDM) extract, dilutions prepared starting from 1:8, 1:16, 1:32, 1:64, 1:128, 1: 256, 1:512, 1:1024,……) |
| Measure | Description | Time Frame |
|---|---|---|
| percentages of the participants that tested positive to house dust mites bronchial provocation | 30 minutes after house dust mites bronchial provocation |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of the percentages of eosinophils in sputum, nasal lavage and fractional exhaled nitric oxide (FeNO) from baseline | 30mins, 7 and 24 hours after bronchial challenge | |
| Changes of provocative concentration induced a 20% decrease in forced expiratory volume at one second (FEV1) to methacholine before and after house dust mites bronchial provocation |
| Measure | Description | Time Frame |
|---|---|---|
| correlate of IL-4,IL-13,periostin with provocative concentration induced a 20% decrease in FEV1 to house dust mite in asthmatic | By Comparison with methacholine provocation test | 30 mins and 24 hours after house dust mites bronchial challenge |
| Incidence and Severity of Adverse Events During The House Dust Mite Bronchial Provocation Test |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jinping Zheng | State Key Laboratory of Respiratory Disease; China Clinical Research Center of Respiratory Disease; First Affiliated Hospital of Guangzhou Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangzhou institute of respiratory disease | Guangzhou | Guangdong | 510120 | China |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D006967 | Hypersensitivity |
| D016535 | Bronchial Hyperreactivity |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D039741 | Antigens, Dermatophagoides |
| ID | Term |
|---|---|
| D000941 | Antigens |
| D001685 | Biological Factors |
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| 24 hours after house dust mites bronchial challenge |
| percentages of the participants that tested positive to house dust mites bronchial provocation measured by impulse oscillometry | 10 minutes after house dust mites bronchial provocation |
| Changes of provocative concentration induced a 60% increase in nasal airway resistance to histamine before and after house dust mites bronchial provocation | By Comparison with methacholine provocation test | 24 hours after house dust mites bronchial challenge |
By Comparison with methacholine provocation test at 30 min and 24 hours after challenge test. |
| 30 minutes, 7 hours and 24 hours after house dust mites bronchial provocation |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D007154 | Immune System Diseases |