Cellular and Molecular Adaptations to Exercise-induced Inflammatory Response in Children With Autoimmune Diseases

Cellular and Molecular Adaptations to Exercise-induced Inflammatory Response in Children With Autoimmune Diseases

Juvenile idiopathic arthritis (JIA) is a chronic disease characterized by persistent joint inflammation. The immune system disruption that leads to overproduction of pro-inflammatory cytokines (TNF-α, IL-1, IL-6) is a cascade of events on different levels-some molecular, some cellular, and some systemic. Our objective is to identify the mechanisms through which physical activity is liable to mediate inflammatory balance in autoimmune disease settings, and specifically in JIA patients.

Feasibility study

Inclusion Criteria:

• Children between 8 and 12 years
• Tanner stage < T2
• polyarthritis, oligoarthritis and ERA sub-type of JIA
• Stable disease during 3 months before starting study

Exclusion Criteria:

• Infection
• Fever
• Anti-IL6 treatment
• More than 6h per week of physical activity
• Systemic corticosteroid treatment during the 3 months before starting study
• Systemic JIA
• JIA not mastered by treatments
• Other autoimmunity or auto-inflammatory diseases
• Participation in another clinical research protocol