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This study aims to describe antiplatelet therapy in ACS in Andalusia and make an assessment of efficacy and safety of hospital use Prasugrel / ticagrelor vs. Clopidogrel and Prasugrel switching to / ticagrelor patients pretreated with clopidogrel.
The management of acute coronary syndrome has changed in recent years as reflected in the new Clinical Practice Guidelines of the European Society of Cardiology for the management of ACS with or without ST segment elevation, with the development and increased accessibility of the angiography and percutaneous coronary intervention and the arrival of the new antiplatelet (Prasugrel and Ticagrelor).
The ACS encompasses several clinical entities where dual antiplatelet therapy remains the basis of antiplatelet therapy and one of the mainstays of treatment. But the emergence of Prasugrel and Ticagrelor have changed the classical management with aspirin plus clopidogre
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute coronary syndrome |
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| Measure | Description | Time Frame |
|---|---|---|
| type of antiplatelet were used | There are the following therapeutic groups: Clopidogrel; Prasugrel; Ticagrelor; Switching to Prasugrel ; Switching toTicagrelor | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| ischemic events after ACS during hospitalization | Ischemic event is defined as the combined end point of stroke, reinfarction, stent thrombosis, restenosis and stent injury retreat previously treated 1. thrombotic complications: stroke, stent restenosis, retreat of the culprit vessel, stent thrombosis, CVA | 3, 6 and 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with acute coronary syndrome
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| Name | Affiliation | Role |
|---|---|---|
| Manuel Almedro Delia, MD | Hospital Universitario Virgen Macarena | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital de Jerez | Cadiz | Spain | ||||
| Hospital de Puerto Real |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37573968 | Derived | Almendro-Delia M, Padilla-Rodriguez G, Hernandez-Meneses B, Blanco-Ponce E, Arboleda-Sanchez JA, Rodriguez-Yanez JC, Soto-Blanco JM, Fernandez-Garcia I, Castillo-Caballero JM, Garcia-Rubira JC, Hidalgo-Urbano R. Nonadherence to ticagrelor versus clopidogrel and clinical outcomes in patients with ACS. Results from the CREA-ARIAM registry. Rev Esp Cardiol (Engl Ed). 2024 Feb;77(2):113-124. doi: 10.1016/j.rec.2023.05.011. Epub 2023 Sep 29. English, Spanish. | |
| 35711382 |
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| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| Total rate of hemorrhage and severity thereof under TIMI9 and BARC15 classification. Also it included as a safety endpoint all-cause mortality. |
bleeding complications: BARC, TIMI classification, transfusions, major bleedingbleeding complications: BARC, TIMI classification, transfusions, major bleeding |
| 3, 6 and 12 months |
| Cadiz |
| Spain |
| Hospital Universitario Reina Sofía | Córdoba | Spain |
| Hospital Universitario Virgen de las Nieves | Granada | Spain |
| Hospital de Antequera | Málaga | Spain |
| Hospital Regional de Málaga | Málaga | Spain |
| Hospital Universitario Virgen de la Victoria | Málaga | Spain |
| Hospital Universitario Virgen Macarena | Seville | Spain |
| Derived |
| Almendro-Delia M, Blanco-Ponce E, Carmona-Carmona J, Arboleda Sanchez JA, Rodriguez Yanez JC, Soto Blanco JM, Fernandez Garcia I, Castillo Caballero JM, Garcia-Rubira JC, Hidalgo-Urbano RJ. Comparative Safety and Effectiveness of Ticagrelor versus Clopidogrel in Patients With Acute Coronary Syndrome: An On-Treatment Analysis From a Multicenter Registry. Front Cardiovasc Med. 2022 May 27;9:887748. doi: 10.3389/fcvm.2022.887748. eCollection 2022. |