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Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.
periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase
COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs.
SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums.
Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SERPINA1 gene in COPD and periodontitis | patients aged between 30-70 yrs with COPD (satisfying Gold's criteria) and chronic periodontitis (>4mm pocket probing depth) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SERPINA1 gene | Genetic | 2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism |
|
| Measure | Description | Time Frame |
|---|---|---|
| SERPINA1 gene polymorphism | of blood samples and running samples by PCR | 9 months |
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Inclusion Criteria:
Exclusion Criteria:
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patients,both male and female aged between 30-70yrs with COPD nd chronic periodontitis
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| Name | Affiliation | Role |
|---|---|---|
| Dr. Sneha Agarwal, PG(perio) | Panineeya Mahavidyalaya institute of dental sciences and research centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr. Sneha Agarwal PG(periodontics) | Hyderabad | Telangana | 500034 | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12492914 | Background | Scott DA, von Ahsen N, Palmer RM, Wilson RF. Analysis of two common alpha 1-antitrypsin deficiency alleles (PI*Z and PI*S) in subjects with periodontitis. J Clin Periodontol. 2002 Dec;29(12):1118-21. doi: 10.1034/j.1600-051x.2002.291212.x. | |
| 7952650 | Background | Travis J, Pike R, Imamura T, Potempa J. The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease. Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 2):S143-6. doi: 10.1164/ajrccm/150.6_Pt_2.S143. |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| ID | Term |
|---|---|
| D000515 | alpha 1-Antitrypsin |
| D017320 | HIV Protease Inhibitors |
| ID | Term |
|---|---|
| D006023 | Glycoproteins |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D015843 | Serpins |
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2ml of blood sample from each subject will be collected in EDTA containing vials and kept at -20 degrees until DNA extraction. the genomic DNA will be isolated and Z/S polumorphism in SERPINA1 gene will be identified by PCR followed by restriction digestion pattern by Alu 1 restriction enzyme.
|
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010455 |
| Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000209 | Acute-Phase Proteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000510 | Alpha-Globulins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
| D000084762 | Viral Protease Inhibitors |
| D011480 | Protease Inhibitors |
| D004791 | Enzyme Inhibitors |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D019380 | Anti-HIV Agents |
| D044966 | Anti-Retroviral Agents |
| D000998 | Antiviral Agents |
| D000890 | Anti-Infective Agents |
| D045506 | Therapeutic Uses |