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In order to determine norm values for skeleton muscle disassembly due to physical exertion in healthy and trained population, and developing a prediction test for approval for rhabdomyolysis injuries to return to duty, 50 healthy subjects will undergo a series of different physical tests.
50 healthy civilians volunteers will be recruited for this study. Each subject will undergo the physical tests: anthropometric measurements, wingate test, VO2max test, step test and running on the anaerobic threshold, on separate days. Blood sample, lactic acid level (measured in blood drop - finger sting) and urine sample will be taken before and after every test.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| experimental protocol | Experimental | 50 healthy, male, trained and aged 18-30 will be recruited and asked to undergo a series of physical tests. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| physical tests | Other | each subject will undergo the following physical tests: day 1 - anthropometric measurements, wingate test and after 1 hour rest VO2max test. lactic acid levels will be measured before and after both tests. day 2 - step test day 3 - running on the anaerobic threshold. blood sample, lactic acid level (measured in blood drop - finger sting) and urine sample will be taken before and after every test in days 2 and 3. |
| Measure | Description | Time Frame |
|---|---|---|
| creatine phosphokinase (CPK) | CPK is a marker for muscle damage assessed in blood test. blood sample will be taken before and after step test and running on the anaerobic threshold test. | 5 experiment days for each subject |
| oxygen consumption (VO2) | VO2 will be monitored continuously using a metabolic system (ERGOTEST 680, ZAN, GERMANY ) during VO2max test, step test and running on the anaerobic threshold test. | 5 experiment days for each subject |
| Measure | Description | Time Frame |
|---|---|---|
| lactic acid | lactic acid level is assessed from blood drop (finger sting), will be taken before and after every test. lactic acid is a marker for anaerobic effort evaluating. | 5 experiment days for each subject |
| Myoglobin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ofir Frenkel, M.D | Contact | +972529243399 |
| Name | Affiliation | Role |
|---|---|---|
| Ofir Frenkel, M.D | Sheba Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sheba medical center | Tel Litwinsky | Ramat- Gan | Israel |
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| ID | Term |
|---|---|
| D012206 | Rhabdomyolysis |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
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marker from urine sample, taken before and after step test and running on the anaerobic threshold test.
| 5 experiment days for each subject |
| Heart rate | The heart rate will be monitored using a wearable heart rate monitor (PolarĀ® sensor and heart rate monitor watch). | 5 experiment days for each subject |