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Decreased exercise capacity and quality of life, increased dyspnea and fatigue perception and hypoxemia during exercise is seen in patients with interstitial lung disease. Impaired ventilatory response, increased lung compliance, ventilation-perfusion mismatching and inadequate peripheral circulation causes decreased exercise capacity. Another important factor that induce decreased exercise capacity is peripheral muscle weakness. In literature, there is no study investigated effects of neuromuscular electrical stimulation on functional exercise capacity, respiratory and peripheral muscle strength, pulmonary functions, physical activity level, dyspnea and fatigue perception in patients with interstitial lung disease.
In literature, there was increased quantity of study investigated effects of neuromuscular electrical stimulation in chronic lung disease patients. It was used as a pulmonary rehabilitation component especially in patients with decreased exercise capacity and peripheral muscle strength, intensely increased dyspnea inhibits exercise. It was demonstrated that neuromuscular electrical stimulation improved functional exercise capacity, peripheral muscle strength and quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NMES Group | Active Comparator | Intervention: NMES group will receive neuromuscular electrical stimulation using high frequency galvanic stimulation and breathing exercises. Neuromuscular electrical stimulation will be applied bilaterally to quadriceps femoris muscle for 3days/6 weeks by a physiotherapist. NMES group will also perform breathing exercises 120 times/day, 7 days/week, for 6 weeks. |
|
| Control Group | Sham Comparator | Sham: Control group will receive breathing exercises. Control group will perform breathing exercises 120 times/day, 7 days/week, for 6 weeks. Control group will be followed-up by telephone once a week. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NMES Group | Other | Neuromuscular electrical stimulation |
| |
| Control Group |
| Measure | Description | Time Frame |
|---|---|---|
| Functional exercise capacity | Six minute walk test | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary functions | Spirometry | 6 weeks |
| Inspiratory and expiratory muscle strength (MIP,MEP) | Mouth pressure device | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Meral Boşnak-Güçlü, PhD | Gazi University | Study Chair |
| Burcu Camcıoğlu, MSc | Gazi University | Study Director |
| Müşerrefe N Karadallı, MSc | Gazi University | Principal Investigator |
| Deran Oskay, PhD | Gazi University | Principal Investigator |
| Haluk Türktaş, Dr | Gazi University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gazi University | Ankara | 06500 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15653996 | Result | Swigris JJ, Gould MK, Wilson SR. Health-related quality of life among patients with idiopathic pulmonary fibrosis. Chest. 2005 Jan;127(1):284-94. doi: 10.1378/chest.127.1.284. | |
| 12917227 | Result | Lama VN, Flaherty KR, Toews GB, Colby TV, Travis WD, Long Q, Murray S, Kazerooni EA, Gross BH, Lynch JP 3rd, Martinez FJ. Prognostic value of desaturation during a 6-minute walk test in idiopathic interstitial pneumonia. Am J Respir Crit Care Med. 2003 Nov 1;168(9):1084-90. doi: 10.1164/rccm.200302-219OC. Epub 2003 Aug 13. |
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| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| Other |
Breathing exercises |
|
| Dyspnea | Modified Borg and Modified Medical Research Council (MMRC) Dyspnea scales | 6 weeks |
| Peripheral muscle strength | Hand held dynamometer | 6 weeks |
| Maximal exercise capacity | Incremental shuttle walk test | 6 weeks |
| Fatigue | Fatigue Severity Scale | 6 weeks |
| Physical activity | Metabolic holter | 6 weeks |
| Cough related quality of life | Leicester Cough Questionnaire | 6 weeks |
| Depression | Montgomery Asberg Depression Rating Scale (MADRS) (Turkish versions of all scales) | 6 weeks |
| Generic quality of life | Short Form (SF-36) Health Survey | 6 weeks |
| Disease specific quality of life | Saint George Quality of Life Questionnaire | 6 weeks |
| 15618580 | Result | Spruit MA, Thomeer MJ, Gosselink R, Troosters T, Kasran A, Debrock AJ, Demedts MG, Decramer M. Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status. Thorax. 2005 Jan;60(1):32-8. doi: 10.1136/thx.2004.022244. |
| 18360183 | Result | Vivodtzev I, Lacasse Y, Maltais F. Neuromuscular electrical stimulation of the lower limbs in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil Prev. 2008 Mar-Apr;28(2):79-91. doi: 10.1097/01.HCR.0000314201.02053.a3. |
| 12454299 | Result | Bourjeily-Habr G, Rochester CL, Palermo F, Snyder P, Mohsenin V. Randomised controlled trial of transcutaneous electrical muscle stimulation of the lower extremities in patients with chronic obstructive pulmonary disease. Thorax. 2002 Dec;57(12):1045-9. doi: 10.1136/thorax.57.12.1045. |
| 19363213 | Result | Sillen MJH, Speksnijder CM, Eterman RA, Janssen PP, Wagers SS, Wouters EFM, Uszko-Lencer NHMK, Spruit MA. Effects of neuromuscular electrical stimulation of muscles of ambulation in patients with chronic heart failure or COPD: a systematic review of the English-language literature. Chest. 2009 Jul;136(1):44-61. doi: 10.1378/chest.08-2481. Epub 2009 Apr 10. |
| 40975137 | Derived | Camcioglu Yilmaz B, Bosnak Guclu M, Keles MN, Oskay D, Turktas H. Effects of neuromuscular electrical stimulation on exercise capacity, muscle strength, physical activity, and quality of life in patients with interstitial lung diseases: A randomized study. Respir Med. 2025 Nov;248:108360. doi: 10.1016/j.rmed.2025.108360. Epub 2025 Sep 18. |
| D008722 | Methods |