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| Name | Class |
|---|---|
| Fundación Mutua Madrileña | OTHER |
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The purpose of this study is to determine the autoantibody profiles after spinal cord injury and their role in spontaneous functional recovery.
Most patients experience variable degrees of functional recovery after spinal cord injury (SCI), predominantly in the first months after lesion. In SCI animal models, autoantibodies are pathogenic and their titers rise up at the time when spontaneous recovery stops. The aim of this study is to determine the autoantibody profiles after SCI and to infer their relation with functional recovery. To achieve this, autoantibody profiles, biochemical, hematological and immune-related parameters (cytokines, chemokines and growth factors) will be determined from a serum blood sample and functional recovery will be evaluated accordingly to standardized scales.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Spinal cord injury | Patients (n=90) will undergo a common arm blood collection to determine autoantibody profiles in serum. This procedure will be performed twice: after recruitment and 3 months later. |
| |
| Controls | Control subjects (n=20) will undergo a common arm blood collection to determine autoantibody profiles in serum. This procedure will be performed only once. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood collection | Other | Blood collection from the subject's arm |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in ASIA scores | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in neurological level of injury | 4 months | |
| Change in ASIA impairment scale (AIS) | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Spinal cord independence measure (SCIM) | Until discharge from the hospital (6-12 months) |
Inclusion Criteria:
Exclusion Criteria:
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Patients with acute spinal cord injury admitted to the Spanish National Hospital for Paraplegics
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| Name | Affiliation | Role |
|---|---|---|
| Angel Arevalo-Martin, PhD | Hospital Nacional de Parapléjicos, SESCAM | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Berufsgenossenschaftliche Unfallklinik Murnau | Murnau am Staffelsee | Germany | ||||
| Hospital Nacional de Parapléjicos, SESCAM |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36200629 | Derived | Leister I, Altendorfer B, Maier D, Mach O, Wutte C, Grillhosl A, Arevalo-Martin A, Garcia-Ovejero D, Aigner L, Grassner L. Trajectory of Serum Levels of Glial Fibrillary Acidic Protein Within Four Weeks Post-Injury Is Related to Neurological Recovery During the Transition from Acute to Chronic Spinal Cord Injury. J Neurotrauma. 2023 May;40(9-10):999-1006. doi: 10.1089/neu.2022.0326. Epub 2022 Dec 9. |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood serum
| Toledo |
| Spain |
| D014947 | Wounds and Injuries |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |