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To investigate the benefit of the application of topical high potency steroid on the incidence of post inflammatory hyperpigmentation after laser treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| laser+steroid 2 days before and after laser | Active Comparator | Before lentigines' treatment with Qs Nd:YAG 532 nm laser, topical 0.05% Clobetasol propionate ointment was applied 2 days on the lesion. Then applied 2 days after the treatment. |
|
| laser+steroid 2 days after laser | Other | Controlled side. Applied topical 0.05% Clobetasol propionate ointment only 2 days after the laser treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| topical 0.05% Clobetasol propionate ointment | Drug | Apply only on the treated area twice a day as mentions |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of post inflammatory hyperpigmentation | By investigator's observation. | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Side effects of topical steroid | By investigators' observation of telangiectasia, erythema or atrophy. | Follow-up 2, 3, 4, 8, 12 and 24 weeks after the last treatment |
| The patients satisfaction |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Woraphong Manuskiatti, M.D. | Department of Dermatology, Siriraj Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine Siriraj Hospital, Mahidol University | Bangkok | Bangkok | 10700 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24292155 | Result | Jun HJ, Cho SH, Lee JD, Kim HS. A split-face, evaluator-blind randomized study on the early effects of Q-switched Nd:YAG laser plus Er:YAG micropeel (combined therapy) versus Q-switched Nd:YAG alone in light solar lentigines in Asians. Lasers Med Sci. 2014 May;29(3):1153-8. doi: 10.1007/s10103-013-1489-9. Epub 2013 Nov 29. | |
| 21384391 |
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| ID | Term |
|---|---|
| D007911 | Lentigo |
| D017495 | Hyperpigmentation |
| ID | Term |
|---|---|
| D008548 | Melanosis |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| Q switched Nd:YAG laser 532 nm | Device | Treatment of facial lentigines. The energy using depends on the endpoint of immediate whitening of the lesions. |
|
By using Quartile grading scale of improvement; 0 = not improve, 1= 1-25% improvement, 2 = 26-50% improvement, 3 = 51-75% improvement and 4 = 76-100% improvement
| Follow-up 4, 8, 12 and 24 weeks after the last treatment |
| Ho SG, Yeung CK, Chan NP, Shek SY, Chan HH. A comparison of Q-switched and long-pulsed alexandrite laser for the treatment of freckles and lentigines in oriental patients. Lasers Surg Med. 2011 Feb;43(2):108-13. doi: 10.1002/lsm.21045. |
| 7963648 | Result | Takiwaki H, Shirai S, Kohno H, Soh H, Arase S. The degrees of UVB-induced erythema and pigmentation correlate linearly and are reduced in a parallel manner by topical anti-inflammatory agents. J Invest Dermatol. 1994 Nov;103(5):642-6. doi: 10.1111/1523-1747.ep12398276. |
| 24854088 | Result | Cheyasak N, Manuskiatti W, Maneeprasopchoke P, Wanitphakdeedecha R. Topical corticosteroids minimise the risk of postinflammatory hyper-pigmentation after ablative fractional CO2 laser resurfacing in Asians. Acta Derm Venereol. 2015 Feb;95(2):201-5. doi: 10.2340/00015555-1899. |