Study of the Angiogenesis by PET/CT in Patients With Lymphoma

Study of the Angiogenesis Measured by PET/CT With 18F-RGD-K5 in Patients With Lymphoma : a Preliminary Study

The aim of the study is to measure tumoral angiogenesis modifications by RGD-K5 PET/CT before and after 2 cycles of chemotherapy in patients with lymphoma and a large tumoral mass

After inclusion PET scans with FDG tracer and with a specific tracer of angiogenesis will be performed on patient with lymphoma. After two cycles of chemotherapy PET scans with the same tracers will be performed.

Overall survival and disease free survival will be monitored during 18 months.

Inclusion Criteria:

• Male or Female
• Age ≥ 18 years old
• OMS ≤ 1
• Histological diagnosis of diffuse large B-cell lymphoma what ever the subtype
• Presence of measurable tumor with at least a node mass superior to 3 centimeters
• Stage I to IV
• Inform consent signed

Exclusion Criteria:

• Primary cerebral lymphoma
• Absence of fixing on FDG-PET exam
• Pregnant , child bearing, breast feeding or without effective contraception method woman
• Hypersensitivity to RGD-K5
• Hypersensitivity to FDG
• Poorly controlled diabètes (glycemia ≥ 10 millimoles/liter)
• Neoplastic disease (less than 2 years or in progression)