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The aim of the study is to measure tumoral angiogenesis modifications by RGD-K5 PET/CT before and after 2 cycles of chemotherapy in patients with lymphoma and a large tumoral mass
After inclusion PET scans with FDG tracer and with a specific tracer of angiogenesis will be performed on patient with lymphoma. After two cycles of chemotherapy PET scans with the same tracers will be performed.
Overall survival and disease free survival will be monitored during 18 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PET scan with RGD K5 imaging | Experimental | PET scan with RGD K5 tracer will be performed before and after two cycles of chemotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RGD K5 PET scan | Device | PET scan with a tracer specific for angiogenesis (RGD K5) will be performed before and after 2 cycles of chemotherapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measure of angiogenesis with RGD K5 PET scan | Measure of fixation, metabolic volume and angiogenic volume with RGD K5 traver | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Measure of angiogenic volume with K5 tracer | Measure of SUV max, SUV peak, SUV mean, metabolic volume and angiogenic volume to determine angiogenesis parameters with RGD-K5 PET scansand correlation with results of anatomopathology. | 3 months |
| Overall survival |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pierre Vera, MD, PhD | Centre Henri Becquerel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Henri Becquerel | Rouen | 76038 | France |
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| ID | Term |
|---|---|
| D008223 | Lymphoma |
| ID | Term |
|---|---|
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
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Time between inclusion and death whatever the cause |
| 18 months |
| Disease-free survival | Time between inclusion and progression or death | 18 months |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |