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| ID | Type | Description | Link |
|---|---|---|---|
| 2010-A00065-34 | Other Identifier | ID-RCB number, ANSM |
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The ELISABET STUDY is across sectional Survey on a representative sample of two urban area conduct on a representative sample. The main objective of the project is to compare the prevalence of the obstructive ventilatory disorders (OVD) in the Urban Community of Dunkirk touched by the industrial pollution in relation to the one recovered in the Urban Community of Lille (CUDL) less industrialized.
Airflow obstruction include Pulmonary Disease, Chronic Obstruction and asthma. Identification of Airflow obstruction is through Functional Tests Lung. In the 1950s, high pollution levels were associated with increased mortality. Despite a reduction of air pollution, it has been established that pollution peaks have short-term effects on acute respiratory episodes. The Urban Community of Dunkirk (CUD) focuses many large pollutant emitters. The long term effects of industrial pollution on TVO are unknown.
The main objective of the project is to compare the prevalence of Airflow obstruction in the Urban Community of Dunkirk affected by industrial pollution compared to that found in the Urban Community of Lille (CUDL) less industrialized. Secondary objectives are: 1) To assess the relationship between air pollution from industrial and biological markers, particularly the plasma concentrations of heavy metals 2) To assess the prevalence of TVO general population in French populations 3) Establish a baseline epidemiological and biological bank.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dunkirk area | Representative sample of Dunkirk and the surrounding urban area (of ~200 000inhabitants).Dunkirk area is characterize by high emission of industrial air pollutant |
| |
| Lille area | Representative sample of Lille and the surrounding urban area (of ~1 million inhabitants, the fourth urban area in France) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| heteroevaluation scale by a nurse or doctor | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| airway obstruction | Forced expiratory volume per second (FEV1) to forced vital capacity (FVC) ratio below 0.7. mesured by standardized spirometry Spirometry testing was performed mostly at home using Micro 6000 spirometers (Medisoft; Sorinnes, Belgium), according to the 2005 ATS/ERS guidelines. The spirometers were calibrated weekly. No bronchodilators were administered. For each participant, the spirometry test was repeated (up to seven times) until three acceptable, reproducible flow-volume loops were obtained, following the same guidelines. The greatest reproducible values of FEV1 and FVC were selected for the statistical analysis (regardless of whether these two values came from separate curves or from the same curve). All spirometry data were validated by an experienced, specialist physician. | during a the single visit scheduled (less than 3 hours in the morning) |
| Measure | Description | Time Frame |
|---|---|---|
| hypertension | Hypertension was defined as ongoing antihypertensive treatment, an Systolic blood pressure >=140 mmHg or a Diastolic Blood pressure >=90 mmHg | during a the single visit scheduled (less than 3 hours in the morning) |
| dyslipidemia |
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Inclusion Criteria:
Exclusion Criteria:
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The participants were selected from electoral rolls by random sampling, with stratification for gender, age and centercentre (Lille or Dunkirk). All participants were all recruited between January 2011 and November 2013. Each selected participant received a letter asking him/her to contact the coordinating team and make an appointment for data collection. In the absence of a reply, participants were contacted by telephone. Data was collected at home (occasionally during a consultation in a healthcare establishment). In all cases, a trained, registered nurse administered a detailed questionnaire and performed spirometry testing.
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| Name | Affiliation | Role |
|---|---|---|
| Luc Dauchet, PhD MD | CHRU LILLE | Principal Investigator |
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Dyslipidemia was defined as ongoing cholesterol-lowering treatment or one or more abnormal fasting blood lipid values (total cholesterol 2.4 g/L, LDLcholesterol>=1.6 g/L, HDLcholesterol <0.4 g/L or blood triglycerides >=2 g/L)
| during a the single visit scheduled (less than 3 hours in the morning) |
| diabetes mellitus | Diabetes mellitus was defined as ongoing antidiabetes treatment (oral medication or insulin) or a fasting blood glucose (FBG) level >=1.26 g/L | during a the single visit scheduled (less than 3 hours in the morning) |
| ID | Term |
|---|---|
| D000402 | Airway Obstruction |
| D006973 | Hypertension |
| D003920 | Diabetes Mellitus |
| D050171 | Dyslipidemias |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D052439 | Lipid Metabolism Disorders |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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