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| Name | Class |
|---|---|
| Jessa Hospital | OTHER |
| Algemeen Ziekenhuis Maria Middelares | OTHER |
| Imelda Hospital, Bonheiden | OTHER |
| AZ Sint-Jan AV |
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Step 1: open baked egg test passed (either at home or in the hospital): this is routine clinical practice; afterwards daily intake of increasing amounts of heated egg (amounts to be noted in diary)
Step 2: open provocation test at home with hard-boiled egg, both hen's egg white and yolk, passed; afterwards weekly intake of either hard-boiled egg white or yolk or both (amounts and days to be noted in diary)
Step 3: open provocation test at home with waffles, omelet, pan cake or scrambled egg passed; afterwards weekly or two-weekly intake of one of these specific preparation forms or of the previous preparation forms (amounts, days and preparation to be noted in diary)
Step 4: open provocation test at home with fried or poached egg or softly boiled egg with liquid yolk; afterwards regular intake of one of these preparation forms or one of the prior steps (amounts, days and preparation to be noted in diary)
Step 5: open provocation test at home with raw egg: eg. In chocolate mousse; mayonnaise or tiramisu; afterwards unlimited intake of all egg containing preparation forms (for 3 months in both groups to be noted in the diary)
If tolerance to a certain step is not yet present (this is: if any reaction occurred during the months registered between two steps), the next step will be postponed. The number of failures (any reaction in relation to egg ingestion), the type of reaction and the additional time period necessary before the next step can be taken, will be recorded. After each time period, the investigators will measure specific IgE to hen's egg white and to Gal d 1, as standard clinical practice.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 18m | Other | arm 18m: 6 months between step 1 and step 2; 6 months between step 2 and step 3, 3 months between all other steps step by step gradual introduction of egg containing food products during 18 months, unless next step can not be taken |
|
| arm 30 m | Other | arm 30m: 9 months between step 1 and step 2; 9 months between step 2 and step 3, 6 months between all other steps step by step gradual introduction of egg containing food products during 30 months, unless next step can not be taken |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| shorter or longer period of specific dietary restrictions | Behavioral | step by step gradual introduction of egg containing food products |
|
| Measure | Description | Time Frame |
|---|---|---|
| time to complete egg tolerance | raw egg tolerance (eg in chocolate mousse) | 18 to 30 months |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of specific IgE to egg white components to predict complete egg tolerance | 18 to 30 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dominique MA Bullens, MD, PhD | UZ Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Leuven | Leuven | Vlaams-Brabant | 3000 | Belgium | ||
| Imelda Hospital, Bonheiden |
data will be analysed and grouped before release
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 30, 2023 | |
| Reset | Feb 12, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 30, 2023 | Feb 12, 2024 |
| ID | Term |
|---|---|
| D021181 | Egg Hypersensitivity |
| ID | Term |
|---|---|
| D005512 | Food Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
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| OTHER |
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| Bonheiden |
| Belgium |
| Sint-Jan | Bruges | 8000 | Belgium |
| Algemeen Ziekenhuis Maria Middelares | Ghent | Belgium |
| Jessa Hospital | Hasselt | Belgium |
| Sint-Jan | Ostend | 8400 | Belgium |