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Whole-body periodic acceleration (WBPA) is a new, non-invasive, and promising therapy for a diverse and growing list of disorders including cardiovascular disease 6. During WBPA, patients lie in the supine position on a bed that is capable of translating back and forth parallel to the ground, along the head-to-foot axis of the patient. Thus, this treatment is best described as a form of "passive exercise." The frequency of the translation (up to 180 cycles/minute; cpm) as well as the distance traveled (2-24mm) by the bed can be adjusted by the patient or health care professional.
The science behind the therapeutic effects of WBPA still remains largely unknown.
The objective of this study is to determine if WBPA may be used as an effective way to reduce lactic acid concentrations during recovery after intense exercise more rapidly than previously established methods.
Each visit Subjects will perform a graded treadmill exercise test. They will rest for 10 minutes. At the end of the rest period, resting vital signs (HR and BP) will be recorded as well as resting oxygen consumption (VO2). Resting capillary blood sample will be taken and analyzed by the Accutrend portable lactate analyzer to measure blood lactate levels. The cardiac and metabolic recordings will be measured by PFT GX machine (Medgraphics Ultima; St. Paul, Minnesota) that will record VO2, VCO2, RER (respiratory exchange ratio), Ve. Heart Rate will be monitored by a Polar® HR monitor. This machine is attached to a motorized treadmill with handrails. Each subject will perform a Modified Bruce Protocol which consists of a maximum of five 3-minute stages. The criteria set for peak exercise is one of the following: 1) 90% of THR; 2) a plateau of oxygen uptake is indicated; 3) if the subject is unable to maintain the pace of the treadmill; 4) an RER of over 1.0 and/or 5) a plateau in Ve (3). Additionally, the American College of Sports Medicine (ACSM) guidelines for terminating exercise testing will be followed(American College of Sports Medicine).
TIMELINE of PROCEDURES
The following recoveries will be tested on 3 separate days:
Visit 1 The subject will walk at 30-40 % of V02 max for the next 20 minutes on the treadmill after peak exercise. Blood lactate will be taken at minute 20.
Visit 2 The subject will be taken off the treadmill after a 3 minute walk and placed on the WBPA bed. The horizontal displacement will be held constant at 14 mm, and cycles/min will be held constant at 140. There is a footboard where the subjects feet are strapped in while wearing their own shoes. The platform moves in a repetitive motion from head-to- foot imparting mild periodic inertial forces in the subject's spinal axis (pGz). Blood lactate will be taken at minute 20.
Visit 3
The subject will be taken off the treadmill after a 3 minute walk and asked to sit in a chair for 20 minutes. Blood lactate will be taken at minute 20.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| WBPA (Whole Body Accleration) | Experimental | Whole-body periodic acceleration (WBPA) is a new, non-invasive, and promising therapy for a diverse and growing list of disorders including cardiovascular disease 6. During WBPA, patients lie in the supine position on a bed that is capable of translating back and forth parallel to the ground, along the head-to-foot axis of the patient. Thus, this treatment is best described as a form of "passive exercise." The frequency of the translation (up to 180 cycles/minute; cpm) as well as the distance traveled (2-24mm) by the bed can be adjusted by the patient or health care professional. |
|
| Active Recovery | Active Comparator | Active recovery methods (e.g.walking, biking) have been shown to decrease blood lactate levels more than passive recovery 1,2. This arm requires subjects to walk at a low intensity as recovery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole Body Periodic Acceleration | Device | A bed that translates back and forth at different frequencies while the subject lies supine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood Lactate | We will use a finger stick to collect plasma post exercise | 20 minutes post exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Oxygen Uptake | Oxygen uptake is measured by a subject wearing a mask that measures what they exhale. | 20 minutes post exercsie |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| New York Institute of Technology | Old Westbury | New York | 11758 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16320173 | Background | Gmada N, Bouhlel E, Mrizak I, Debabi H, Ben Jabrallah M, Tabka Z, Feki Y, Amri M. Effect of combined active recovery from supramaximal exercise on blood lactate disappearance in trained and untrained man. Int J Sports Med. 2005 Dec;26(10):874-9. doi: 10.1055/s-2005-837464. | |
| 8803508 | Background | Taoutaou Z, Granier P, Mercier B, Mercier J, Ahmaidi S, Prefaut C. Lactate kinetics during passive and partially active recovery in endurance and sprint athletes. Eur J Appl Physiol Occup Physiol. 1996;73(5):465-70. doi: 10.1007/BF00334425. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Aug 19, 2019 | |
| Reset | Sep 12, 2019 | |
| Release | Dec 2, 2022 | |
| Reset | Dec 28, 2022 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Aug 19, 2019 | Sep 12, 2019 | |||
| Dec 2, 2022 |
| ID | Term |
|---|---|
| D000140 | Acidosis, Lactic |
| ID | Term |
|---|---|
| D000138 | Acidosis |
| D000137 | Acid-Base Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| 23820561 | Background | Brown J, Glaister M. The interactive effects of recovery mode and duration on subsequent repeated sprint performance. J Strength Cond Res. 2014 Mar;28(3):651-60. doi: 10.1519/JSC.0b013e3182a1fe28. |
| 16236957 | Background | Sackner MA, Gummels E, Adams JA. Effect of moderate-intensity exercise, whole-body periodic acceleration, and passive cycling on nitric oxide release into circulation. Chest. 2005 Oct;128(4):2794-803. doi: 10.1378/chest.128.4.2794. |
| 15653959 | Background | Sackner MA, Gummels E, Adams JA. Nitric oxide is released into circulation with whole-body, periodic acceleration. Chest. 2005 Jan;127(1):30-9. doi: 10.1378/chest.127.1.30. |
| 18357918 | Background | Kohler M, Amann-Vesti BR, Clarenbach CF, Brack T, Noll G, Russi EW, Bloch KE. Periodic whole body acceleration: a novel therapy for cardiovascular disease. Vasa. 2007 Nov;36(4):261-6. doi: 10.1024/0301-1526.36.4.261. |
| Dec 28, 2022 |