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Difficulty recruiting. Study aims now overlap standard of care assessments and future planned studies.
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This study is looking at the feasibility of performing frailty assessments on elderly patients with advanced cancers
This study is primarily looking to see if it is feasible to assess frailty in patients age 70 years and above with advanced cancers. it is also evaluating whether there may be any correlation between these assessments and toxicity and treatment and outcome.
The assessments include: Frailty score, nutritional assessment, comorbidity score and quality of life. In addition sarcopenia will be assessed using timed walk, grip strength and muscle mass measurement from imaging performed as part of routine clinical care.
The assessments will be performed at baseline, week 12 and week 24.
There is the option for patients to also donate blood samples for research purposes.
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| Measure | Description | Time Frame |
|---|---|---|
| Percentage patients consenting for assessments out of number approached | Number of patients consenting for the study as a percentage of number of patients approached about the study. | Baseline |
| Time taken to complete assessments | Length of time participants take to complete study assessments | Baseline, week 12 and week 24 |
| Measure | Description | Time Frame |
|---|---|---|
| Frailty as a predictor of grade 3/4 toxicity | Evaluate whether there is a possible correlation between frailty score at baseline and development of grade 3/4 toxicity during anticancer treatment | baseline |
| Sarcopenia as a predictor of outcome |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with advanced cancers
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| Name | Affiliation | Role |
|---|---|---|
| Alastair Greystoke, MRCP, PhD, MBChB, MSc | Newcastle University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Newcastle upon Tyne NHS Trust | Newcastle upon Tyne | NE7 7DN | United Kingdom |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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Blood samples and baseline, week 12 and weeks 24
sarcopenia at baseline and over time as a predictor of outcome
| baseline, week 12 and week 24 |
| Quality of life EORTC QCQ 30 | Participants complete EORTC QCQ 30 questionnaire | baseline, week 12 and week 24 |
| Biomarker assessment of frailty and associated factors which may include genetic analysis | Assessment of frailty biomarkers in blood samples | baseline, week 12 and week 24 |