A Study to Evaluate the Effects of Tedizolid Phosphate on the Pharmacokinetics and Safety of Midazolam and Rosuvastatin (MK-1986-004)

A Multiple-Dose Study to Evaluate the Effects of Steady-State Tedizolid Phosphate Administration on the Pharmacokinetics and Safety of a Single Dose of Midazolam and Rosuvastatin

The purpose of this study is to assess the effect of steady-state tedizolid phosphate on the single-dose pharmacokinetics of midazolam and rosuvastatin in healthy, adult participants.

Inclusion Criteria:

• healthy, adult males or females (women of non-childbearing potential)
• continuous non-smokers who have not used nicotine-containing products for the previous 3 months

Exclusion Criteria:

• mentally or legally incapacitated or has significant emotional problems
• history or presence of clinically significant medical or psychiatric condition or disease
• history or presence of alcoholism or drug abuse within the past 2 years
• female participants who are pregnant, lactating, or of childbearing potential
• donated blood or had significant blood loss within 56 days prior to first dose of study drug
• plasma donation within 7 days prior to first dose of study drug