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The purpose of this study is to evaluate the effect of zinc supplementation in the treatment for dysgeusia, progression disease and quality of life in patients with liver cirrhosis.
Taste disorders are symptomatologies in patients with cirrhosis, these have a direct effect in modification of food consumption, increasing weight loss, anorexia and malnutrition, which impacts in decompensation rates and mortality.
It has been proposed that zinc deficiency is one of the causes for development of taste disorders. The aim of this study is to describe the presence of taste disorders in patients with cirrhosis and evaluate the effect of zinc supplementation in treatment of taste disorders, and in progression of chronic liver disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 100 mg placebo | Placebo Comparator | 100 mg Placebo plus nutritional education |
|
| 100 mg zinc supplement | Experimental | Nutritional education plus 100 mg of zinc gluconate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| zinc gluconate | Dietary Supplement | Zinc supplementation plus nutritional education |
|
| Measure | Description | Time Frame |
|---|---|---|
| Dysgeusia | Evaluation of presence of any taste disorder, according to questionnaires and evaluation of perception and recognition thresholds with ascending molar concentrations of basic tastes. | Presence of any taste disorder at 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Norberto C Chávez-Tapia, PhD | Contact | 54246850 | nchavezt@medicasur.org.mx | |
| Eva Juárez-Hernández | Contact | 54246850 | evajuarezh@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Norberto C Chávez-Tapia, PhD | Medica Sur Clinic & Foundation | Principal Investigator |
| Eva Juárez-Hernández | Medica Sur Clinic & Foundation | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medica Sur Clinic & Foundation | Recruiting | Mexico City | 14050 | Mexico |
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| ID | Term |
|---|---|
| D004408 | Dysgeusia |
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D013651 | Taste Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| C030691 | gluconic acid |
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| Placebo | Dietary Supplement |
|
| Nutritional education | Behavioral |
|
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |