Observational Study of Thrombogenic Properties in 220 Patients With Proximal Femur Fracture

Observational Study of Thrombogenic Properties in 220 Patients With Proximal Femur Fracture

Measurement of thrombogenic properties by TEG and MEA and observation of thrombotic events over 2 years in 220 patients with hip fracture.

Patients with proximal femur fracture have high incidences of thrombotic events. By the two "bed-side" methods TEG (Thrombelastography) and MEA (Multiple Electrode Aggregometry), the thrombogenic properties of 220 patients with proximal femur fracture will be measured at time of hospital admission and 4 times over a period of 6 months postoperatively, and the patients will be followed in a total length of 2 years to register thrombotic events.

Inclusion Criteria:

• Patients older than 18 years who are admitted to our hospital for orthopedic surgery of proximal femur fracture.
• The study participants must be capable to sign/accept informed concent

Exclusion Criteria:

• Patients with severe dementia or that of other causes not ar capable to give informed concent.
• Patients with known or suspected cancer, blood diseases or bleeding disorders
• Surgery last 6 months
• Severe renal- (eGFR (creatinine) <30)
• Severe hepatic failure (2x UNL for bilirubin, 3x UNL for ALAT or INR > 1,3 without anticoagulation treatment)
• Patients that, by drug spesification or -SPC, not are eligible for postoperative thrombosis prophylaxis