Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The loss of ability to walk in many children with DMD (Duchenne muscular Dystrophy) is a pejorative event. Biomechanical and morphological unknowledge about the loss of the walk ability in children with DMD is an obstacle in reeducative, pharmacological or surgical therapeutic targets.
The loss of ability to walk in many children with DMD (Duchenne muscular Dystrophy) is a pejorative event. Biomechanical and morphological unknowledge about the loss of the walk ability in children with DMD is an obstacle in reeducative, pharmacological or surgical therapeutic targets. We suppose that there are muscular characteristics and predictive parameters of the loss of walk ability. The identification of these potential therapeutic targets would improve the surveillance and the clinical care but would also guide future clinical and fundamental trials too.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Duchenne muscular dystrophy children | Other | No drug and no placebo were used in this study. For 2h30 (time)
|
|
| Healthy children | Other | No drug and no placebo were used in this study. For 2h30 (time)
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No drug and no placebo were used in this study | Other | measures of muscular strength of legs, motor function, walk testing and analysis (3D video recording), RMI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Determine biomechanical and morphological predictive factors of the loss of the walk ability of the children with DMD | Determine the biomechanical factors (muscular atrophy, muscular strength, muscular shrinkage) and morphological (greasy infiltration, contractile portion, muscular geometry) predictive of the loss of the walk ability of the children with DMD | 24 years |
| Measure | Description | Time Frame |
|---|---|---|
| Identify the muscles wasting and their implication in the loss of strength and the walking ability | Identify the muscles wasting and their implication in the loss of strength and walking. This will be made possible thanks to the predictive analysis and the evolutionary analysis of the MRI and strength before and after loss of walking ability | 24 years |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sylvain BROCHARD, Dr | Contact | 02 98 22 31 52 | sylvain.brochard@chu-brest.fr |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU | Recruiting | Brest | Brittanny | 29609 | France |
Not provided
| ID | Term |
|---|---|
| D020388 | Muscular Dystrophy, Duchenne |
| ID | Term |
|---|---|
| D009136 | Muscular Dystrophies |
| D020966 | Muscular Disorders, Atrophic |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Biomechanical evolutionary data collected during the last 2 years of walking | Biomechanical evolutionary data collected during the last 2 years of walking by the repetition of the analysis of the walking until the loss of the walking ability. | 24 years |
| Establish the relationship between the parameters of walking and the scrawny body morphological anomalies | Establish the relationship between the parameters of walking and the scrawny body morphological anomalies (muscular Atrophy, greasy infiltration, contractile muscular portion, three-dimensional morphological parameters) by doing correlations analysis | 24 years |
| CHRU | Not yet recruiting | Lille | North | 59037 | France |
|
| CHRU | Not yet recruiting | Angers | 49933 | France |
|
| CH Le Mans | Not yet recruiting | Le Mans | 72650 | France |
|
| CHU | Recruiting | Lyon | 63677 | France |
|
| CHU de Nantes | Recruiting | Nantes | 44093 | France |
|
| CHU | Not yet recruiting | Poitiers | 86021 | France |
|
| CHU | Not yet recruiting | Rennes | 35033 | France |
|
| CHRU | Not yet recruiting | Tours | 37044 | France |
|
| CHBA | Not yet recruiting | Vannes | 56017 | France |
|
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D040181 | Genetic Diseases, X-Linked |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |