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The management of functional psychogenic movement disorders (FNPMD) is challenging for neurologists and psychiatrists and only comprehensive multidisciplinary treatment programme can be worthwhile for these patients (Moene et al 2002). Recent functional magnetic resonance imaging studies have demonstrated abnormalities in motor control at cortical level, hyperactivity of limbic system and disturbance of connectivity between these two systems leading to a lack of self-agency, (Voon et al 2010,2011).Two recent studies suggested a possible therapeutic effect of transcranial magnetic stimulation (TMS) in FNPMD (Dakotakis 2011, Garcin, 2013).
In this protocol our objectives are twofold :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| active rTMS | Experimental | 12 patients will be enrolled in this arm. |
|
| sham rTMS | Sham Comparator | 12 patients will be enrolled in this arm. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rTMS | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Psychogenic Movement Disorder Rating Scale (PMDRS= Hinson score between baseline and one month after rTMS treatment | Inclusion and 1 month later |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Global Impression-Severity scale (CGI-SEVERITY/CGI-I/CGI-S) | inclusion, inclusion + 5 days, inclusion + 1 month, inclusion + 2 months, inclusion + 6 months, inclusion + 12 months. | |
| Hospital Anxiety and Depression Scale (HAD/HDRS) | inclusion, inclusion + 1 month, inclusion + 6 months, inclusion + 12 months. |
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Inclusion criteria:
Exclusion criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Toulouse University Hospital | Toulouse | 31000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21480152 | Background | Dafotakis M, Ameli M, Vitinius F, Weber R, Albus C, Fink GR, Nowak DA. [Transcranial magnetic stimulation for psychogenic tremor - a pilot study]. Fortschr Neurol Psychiatr. 2011 Apr;79(4):226-33. doi: 10.1055/s-0029-1246094. Epub 2011 Apr 8. German. | |
| 23385844 | Background | Garcin B, Roze E, Mesrati F, Cognat E, Fournier E, Vidailhet M, Degos B. Transcranial magnetic stimulation as an efficient treatment for psychogenic movement disorders. J Neurol Neurosurg Psychiatry. 2013 Sep;84(9):1043-6. doi: 10.1136/jnnp-2012-304062. Epub 2013 Feb 5. |
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| ID | Term |
|---|---|
| D009069 | Movement Disorders |
| ID | Term |
|---|---|
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Quality of Life (SF-36) | inclusion, inclusion + 1 month, inclusion + 2 months, inclusion + 6 months, inclusion + 12 months. |
| Temperament and Character Inventory (TCI) | inclusion, inclusion + 12 months. |
| Pain scale (VAS) | : inclusion, inclusion + 5 days, inclusion + 1 month, inclusion + 2 months, inclusion + 6 months, inclusion + 12 months. |
| 31180620 | Result | Taib S, Ory-Magne F, Brefel-Courbon C, Moreau Y, Thalamas C, Arbus C, Simonetta-Moreau M. Repetitive transcranial magnetic stimulation for functional tremor: A randomized, double-blind, controlled study. Mov Disord. 2019 Aug;34(8):1210-1219. doi: 10.1002/mds.27727. Epub 2019 Jun 10. |