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The breast cancer screening and diagnostic period is associated with heightened symptoms of anxiety and depression. Physical exercise has been found to effectively decrease these symptoms in healthy and diseased populations. This study aims to determine if a pre treatment exercise intervention can minimize symptoms of anxiety and depression in women undergoing screening for breast cancer.
The breast cancer diagnostic process is associated with anxiety and depression. Physical exercise has emerged as an attractive non-pharmacologic approach to mitigating the psychological and physical sequelae of breast cancer and its treatments, however pre treatment interventions are not integrated into current practice. This study aims to determine the effectiveness and feasibility of a pre treatment exercise intervention in attenuating levels of anxiety and depression following breast biopsy and throughout the diagnostic period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Self Management | Experimental | In addition to the weekly supervised exercise session, participants in this arm will view an instructional video. The video will deliver theory driven training of cognitive behavioural strategies for self management of exercise. It is expected that this will improve adherence to the exercise program. |
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| Exercise | Experimental | Personalized 6 week moderate intensity (50 - 75% of heart rate reserve) facility and home based exercise program including cardiovascular and muscular conditioning. |
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| Prospective Cohort Control | No Intervention | Eligible, consented participants who are unable to attend the weekly exercise sessions will serve as a cohort control group. Participants will be asked to complete patient reported measures of anxiety, depression, and exercise behaviour within 3 days of biopsy, and 6 weeks post biopsy. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Moderate intensity exercise training | Behavioral | 6 weeks of moderate intensity exercise training (50 - 75% of heart rate reserve). Sessions are facility and home based and include cardiovascular warm-up, cardiovascular training, muscular conditioning, and flexibility exercises. |
| Measure | Description | Time Frame |
|---|---|---|
| Symptoms of anxiety will be assessed using patient reported anxiety inventory | Spielberger State-Trait Anxiety Inventory - State Form (STAI; Spielberger, Gorsuch, & Lushene, 1970). | Change in baseline (within 1 week of breast biopsy) at Week 3 and at Week 6 |
| Measure | Description | Time Frame |
|---|---|---|
| Symptoms of subclinical depression will be assessed using a patient reported inventory | Centre for Epidemiologic Studies-Depression Scale (CES-D; Radloff, 1977). | Within 1 week of breast biopsy, Week 3, Week 6 |
| Exercise behaviour will be assessed using a patient reported inventory |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Muriel Brackstone, MD PhD FRCSC | London Regional Cancer Program | Study Director |
| Anita G Cramp, PhD | Western University | Study Director |
| Amy Kossert, MHK | Western University | Study Director |
| Harry Prapavessis, PhD | Western University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Exercise and Health Psychology Laboratory, Western University | London | Ontario | N6A 3K7 | Canada |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| D001008 | Anxiety Disorders |
| D003863 | Depression |
| D009043 | Motor Activity |
| D004194 | Disease |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D000073278 | Self-Management |
| D017009 | Professional Autonomy |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Self Management of exercise | Behavioral | In addition to the 6 week exercise program (refer to Exercise Treatment Group), participants randomly assigned to the Self Management Group will learn strategies for the self management of exercise. |
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Leisure Time Exercise Questionnaire (Godin & Shephard, 1985) |
| Within 1 week of breast biopsy, Week 3, Week 6 |
| Body composition: Dual X-Ray Absorptiometry scan (GE Lunar iDXA) | Baseline (within 1 week of breast biopsy), Week 6 |
| Self Efficacy: patient reported inventory assessing efficacy for self management of exercise | 1 week post breast biopsy, Week 3, Week 6 |
| Optimism: patient reported inventory assessing dispositional optimism | Life Orientation Test-Revised (LOT-R; Scheier, Carver, & Bridges, 1994). | Baseline (within 1 week of core breast biopsy) |
| Symptoms of dispositional anxiety will be assessed using patient reported anxiety inventory | STAI - Trait Form | Within 1 week of breast biopsy |
| D017437 |
| Skin and Connective Tissue Diseases |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012046 | Rehabilitation |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D011364 | Professional Practice |
| D009934 | Organization and Administration |
| D006298 | Health Services Administration |