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| Name | Class |
|---|---|
| Sahlgrenska University Hospital | OTHER |
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Iron deficiency anaemia is a major problem for women worldwide. Cereal foods are a major source of iron, but much of this is not bioavailability due to it being bound by the high amounts of phytate present in cereals. Destruction of phytate by the phytase enzyme can release iron and increase its bioavailability. In a human cell model of iron uptake, sourdough fermentation, which included activation of phytase, the enzyme that breaks down phyate, led to improved iron bioavailability. This clinical trial will attempt to demonstrate that this concept also works in humans
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Whole grain rye bread | Placebo Comparator | Whole grain rye bread, 200 g/d. Control intervention. |
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| Whole grain sourdough rye bread | Experimental | Whole grain rye bread, 200 g/d. Experimental intervention. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whole grain rye bread | Other | Whole grain rye bread baked without sourdough fermentation (normal yeast-based fermentation) |
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| Measure | Description | Time Frame |
|---|---|---|
| Serum ferritin | 12 week values corrected for baseline | |
| Serum transferrin receptor | 12 week values corrected for baseline | |
| Haemoglobin | 12 week values corrected for baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D000740 | Anemia |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| Whole grain sourdough rye bread | Other | Whole grain rye bread fermented with sourdough culture before baking |
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