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The purpose of this project is to study the effect of dietary supplementation with a natural health product (NHP) with a focus on its effects on its levels in breast milk.
The effect of oral cysteine on its levels in breast milk and plasma will be measured in breast feeding mothers.
The investigators will not be studying tryptophan and tyrosine in this study. The title is an overview title left over from other past studies (but the investigators are only assessing cysteine at this time).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No supplement | No Intervention | This group subjects will not receive the supplement | |
| 1.5 gram of l-cysteine | Active Comparator | Intervention: single dose of 1.5 g L-Cysteine. |
|
| 3 grams of l-cysteine | Active Comparator | Intervention: single dose of 3.0 g L-Cysteine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-Cysteine | Dietary Supplement | The trade name is New Root Herbal Inc. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Breast milk cysteine levels | measurement of amino acid before and after acute administration over a 10 hour period
| The main protocol occurs of 10 hours of time when the pharmacokinetics of the amino acid are measured. |
| Measure | Description | Time Frame |
|---|---|---|
| plasma cysteine levels | These are the acute changes in plasma cysteine levels over 10 hours | These are sampled over 10 hours before and after administration of cysteine |
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Inclusion Criteria:
Other general medical requirements for inclusion:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeff Meyer, MD,PhD | Centre for Addiction and Mental Health, Research Imaging Centre, Toronto, Ontario, Canada M5T 1R8 | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Imaging Centre, Centre for Addiction and Mental Health | Toronto | Ontario | M5T 1R8 | Canada |
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| Label | URL |
|---|---|
| Information about research at the Centre for Addiction and Mental Health | View source |
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| ID | Term |
|---|---|
| D003545 | Cysteine |
| ID | Term |
|---|---|
| D000603 | Amino Acids, Sulfur |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D013438 | Sulfhydryl Compounds |
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| D021542 |
| Amino Acids, Neutral |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |