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The aim of the study is to determine the efficacy and safety of treatment with the drug eplerenone in patients with chronic central serous chorioretinopathy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Experimental | Treatment: Eplerenone (Inspra) All patients will receive 25mg eplerenone once a day for a week, followed by 50mg once a day, for a total of 4-12 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Inspra (eplerenone) | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Resolution of sub-retinal fluid measured by optical coherence tomography (OCT). | 6 months | |
| Number of Participants with Adverse Events as a Measure of Safety and Tolerability. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in macular volume at baseline, during and after the treatment with eplerenone. | 6 months | |
| Changes in visual acuity at baseline measured on Early Treatment of Diabetic Retinopathy Study (ETDRS) chart, during and after the treatment with eplerenone. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Semmelweis University, Department of Ophthalmology | Budapest | 1085 | Hungary |
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| ID | Term |
|---|---|
| D000077545 | Eplerenone |
| ID | Term |
|---|---|
| D007783 | Lactones |
| D009930 | Organic Chemicals |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 |
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| 6 months |
| Changes in choroideal thickness at baseline measured by OCT, during and after the treatment with eplerenone in both eyes. | 6 months |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |