This study evaluate multiple-portal VATS and uniportal VATS lobectomy for NSCLC, half of participants will receive multiple VATS, while the other half will receive uniportal VATS lobectomy.

Conventional VATS and uniportal VATS lobectomy can be performed each for NSCLC. Conventional VATS lobectomy employ 3 or 4 ports for completing the operation. Usually the camera port is performed at the seventh or eighth intercostals space within the trocar, so it's easy to cause the intercostals nerve and vessel injure, and still create obvious pain.

However, the lobectomy for lung cancer can be accomplished with a single incision. According to the initial results, Uniportal VATS (UVATS) lobectomy procedure has been wide adopted by less acess trauma, relieve postoperative pain. But these were retrospective and descriptive, not randomized study. Further randomized control studies will be required to demonstrate that there are more benefits in UVATS techniques compared with conventional VATS for lobectomy.

Inclusion Criteria:

• Patients with clinical diagnosis of primary lung cancer with the age between 35 and 75 years old;
• Patients with Tumor size ≤5cm，clinically staged T1-2N0-1M0，prepared for lobectomy and mediastinal lymph node dissection;
• Patients with an American Society of Anesthesiology score of 0-1.

Exclusion Criteria:

• Patients with N2 or N3 positive or distant metastasis.
• Patients who had undergone Neoadjuvant chemotherapy.
• Patients with tumor invasion to the peripheral structures.
• Patients with previous history of thoracic operations.
• Patients with serious thoracic adhesion.
• Patients who will undergo Pneumonectomy, sleeve lobectomy, segmentectomy, wedge resection.
• Patients with preexisting chronic obstructive pulmonarydisease, asthma, or interstitial lung disease;
• Patients with cardiac, hepatic, or renal dysfunction;