Irreversible Electroporation Ablation for Colorectal Metastases to the Lung

Irreversible Electroporation Ablation for Colorectal Metastases to the Lung

The investigators are investigating the use of a new cancer treatment called Irreversible Electroporation (IRE). This treatment delivers electrical energy between two needles placed in a cancer. The electrical energy causes cells to die. While this has been used in patients for different applications, the investigators are trying to understand how safe and well it works in colon cancer that has spread to the lung. Once the irreversible electroporation procedure is completed during the operation, the surgeon will then remove the cancer according to standard procedure. As part of the study, they will be measuring safety of the electrical energy delivered and will be reviewing the resected specimen under the microscope.

Inclusion Criteria:

• Diagnosed Colorectal cancer with oligometastatic colorectal cancer in the lung
• Lung lesion size is greater than 1 cm
• Patient will undergo surgical resection as per consultation with their thoracic surgeon and medical oncologist
• Patient is cleared to undergo paralytic anesthesia.
• Patients 18 years old and older

Exclusion Criteria:

• Patients with history of cardiac dysrhythmia
• Known heart failure (EF < 40%)
• Pacemaker/defibrillator
• Patient's with any metallic cardiac implant
• Patient on anti-coagulation therapy and are unable to stop therapy for the perioperative period
• Women who are pregnant and/or nursing