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Attention biases in threat processing have been assigned a prominent role in the etiology and maintenance of anxiety disorders. Attention Bias Modification Treatment (ABMT) utilizes computer-based protocols to implicitly modify biased attentional patterns in anxious patients. This is a double-blind randomized controlled trial of ABMT for clinically anxious 10-18 year-olds. Participants will be assessed using clinical interviews and parent- and self-rated questionnaires before, in the middle and after twelve sessions of ABMT or control groups, and again at ten-week follow-up. Outcome measures will be anxiety symptoms and depression as measured by gold standard questionnaires as well as structured clinical interviews with youth and their parents. Attentional threat bias, Attentional control and interpretation of ambiguous information will also be measured to explore potential mediators of ABMT's effect on anxiety. The investigators expect the findings to inform pathways to treatments for anxious children and to provide initial information on mechanisms of ABMT efficacy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Attention Bias Modification treatment (ABMT) | Experimental | Attention training via repeated trials of a dot-probe task intended to direct attention away from threat stimuli using threat and neutral face stimuli. |
|
| Exposure only +ABMT | Active Comparator | Identical discrimination task including exposure to a single threat or neutral face stimulus in each trial. |
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| Attention training only +ABMT | Active Comparator | Attention training via repeated trials of a dot-probe task using non-emotional stimuli. |
|
| Placebo group | Placebo Comparator | Identical discrimination task including a single non-emotional stimulus in each trial. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Attention Bias Modification treatment (ABMT) | Behavioral | Attention training via repeated trials of a dot-probe task intended to direct attention away from threat stimuli using threat and neutral face stimuli. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in anxiety symptoms - the Pediatric Anxiety Rating (PARS) | The PARS assesses global anxiety severity across different anxiety disorders in youth. | 4 weeks, 8 weeks, and 18 weeks (follow-up) |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in anxiety related emotional disorders symptoms - Child/Parent Version (SCARED-C/P) | The SCARED is a 41-item self and parent-report instrument designed to assess anxiety in children and adolescents. | 4 weeks, 8 weeks, and 18 weeks (follow-up) |
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Inclusion Criteria:
Exclusion Criteria: To be excluded youth must:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tel-Aviv University | Tel Aviv | Israel |
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| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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| Exposure only +ABMT | Behavioral | Identical discrimination task including exposure to a single threat or neutral face stimulus in each trial. |
|
| Attention training only +ABMT | Behavioral | Attention training via repeated trials of a dot-probe task using non-emotional stimuli. |
|
| Placebo group | Behavioral | Identical discrimination task including a single non-emotional stimulus in each trial. |
|