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| Name | Class |
|---|---|
| University Hospital Tuebingen | OTHER |
| Universitätsklinikum Hamburg-Eppendorf | OTHER |
| University Hospital, Aachen | OTHER |
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This study aims to evaluate the impact of contact isolation on the rate of hospital-acquired transmissions of ESBL-producing Escherichia coli (ESBL-EC) and the rate of colonization and infection. On the basis of this study, it will be possible to re-evaluate the need for contact isolation for patients colonized or infected with ESBL-EC.
The study aims to evaluate the impact of contact isolation on the rate of hospital-acquired transmissions of ESBL-producing Escherichia coli and the rate of colonization and infection.
Hematological and oncological wards in hospitals with a non-outbreak setting for ESBL-EC and adhering to at least the following standard of care are eligible for study participation:
Sites will be grouped according to their approach regarding contact isolation (see group description).
As a control for external factors a hand hygiene program, including training and adherence assessments, will be implemented.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Centers using contact isolation |
Contact isolation must include:
| ||
| Centers using no contact isolation |
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| Measure | Description | Time Frame |
|---|---|---|
| Incidence of hospital-acquired ESBL-EC colonization or infection | up to 12 month |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of patient-to-patient transmission of ESBL-EC defined by the isolation of two or more ESBL-EC strains from two or more different patients with overlapping hospitalization periods in the same ward, related to each other on the basis of molecular | up to 12 month | |
| Incidence of ESBL-EC intestinal colonization among all patients (colonization is defined as the isolation of ESBL-EC in material from fecal screening) |
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Inclusion Criteria:
Exclusion Criteria:
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All admitted patients on participating hematological and oncological wards in hospitals with a non-outbreak setting for ESBL-EC.
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| Name | Affiliation | Role |
|---|---|---|
| Maria JG Vehreschild, PD Dr. | university clinic of cologne | Principal Investigator |
| Oliver A Cornely, Prof Dr. | university clinic of cologne | Principal Investigator |
| Jörg J Vehreschild, PD Dr. | university clinic of cologne | Principal Investigator |
| Harald Seifert, Prof. Dr. | university clinic of cologne | Principal Investigator |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Dec 18, 2023 | |
| Reset | Jun 14, 2024 | |
| Release | Apr 2, 2025 | |
| Reset | Apr 21, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Dec 18, 2023 | Jun 14, 2024 | |||
| Apr 2, 2025 |
| ID | Term |
|---|---|
| D006402 | Hematologic Diseases |
| ID | Term |
|---|---|
| D006425 | Hemic and Lymphatic Diseases |
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Rectal swabs or stool samples
| up to 12 month |
| Incidence of ESBL-EC bloodstream infections among all patients (ESBL-EC bloodstream infection is defined by the isolation of ESBL-EC from blood cultures) | up to 12 month |
| Incidence of ESBL-EC bloodstream infections among previously colonized patients - Readmission fraction associated with infection with ESBL-EC | up to 12 month |
| Incidence of ESBL-Klebsiella pneumonia (ESBL-KP) colonized patients among all patients (colonization is defined as the isolation of ESBL-KP in material from fecal screening) | In theory, the ability to produce ESBL can be transferred between species by plasmids. However, in clinical practice, this seems to be an extremely rare event. Nevertheless, it should be assessed to detect any potential risks to patients at sites not isolating for ESBL-EC. | up to 12 month |
| Incidence of ESBL-KP bloodstream infections among all patients (ESBL-EC bloodstream infection is defined by the isolation of ESBL-KP from blood cultures) | In theory, the ability to produce ESBL can be transferred between species by plasmids. However, in clinical practice, this seems to be an extremely rare event. Nevertheless, it should be assessed to detect any potential risks to patients at sites not isolating for ESBL-EC. | up to 12 month |
| Incidence of ESBL-KP bloodstream infections among previously colonized patients | In theory, the ability to produce ESBL can be transferred between species by plasmids. However, in clinical practice, this seems to be an extremely rare event. Nevertheless, it should be assessed to detect any potential risks to patients at sites not isolating for ESBL-EC. | up to 12 month |
| Apr 21, 2025 |