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| ID | Type | Description | Link |
|---|---|---|---|
| UL1TR001082 | U.S. NIH Grant/Contract | View source | |
| R01MH102224 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
| National Center for Advancing Translational Sciences (NCATS) | NIH |
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This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise intervention | Experimental | 10 weeks of a moderate exercise intervention |
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| Diet intervention | Active Comparator | 10 weeks of a diet intervention |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral |
| ||
| Diet |
| Measure | Description | Time Frame |
|---|---|---|
| Neuronal response to visual food cues | Neuronal response (insula) while viewing visual food cues | 14 weeks |
| Resting-state neuronal response | Neuronal response (default mode network) during rest | 14 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Appetite Rating on a visual analogue scale (VAS) | Participants will be asked to rate their hunger via Hunger ratings on a VAS | 14 weeks |
| Fasting leptin | Fasting blood levels of leptin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kristina T Legget, Ph.D. | Contact | 303-724-5809 | kristina.legget@ucdenver.edu |
| Name | Affiliation | Role |
|---|---|---|
| Jason Tregellas, Ph.D. | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz Medical Campus | Recruiting | Aurora | Colorado | 80045 | United States |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D004032 | Diet |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 14 weeks |
| Fasting ghrelin | Fasting blood levels of ghrelin | 14 weeks |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |