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| Name | Class |
|---|---|
| University of Helsinki | OTHER |
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To study the multimodal protocol combining adjunct dexmedetomidine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Active Comparator | Oxycodone 1 mg / ml alone |
|
| Dexmedetomidine 2.5 | Active Comparator | Oxycodone 1 mg / mL + Dexmedetomidine 2,5 μg / mL |
|
| Dexmedetomidine 5 | Active Comparator | Oxycodone 1 mg / mL + Dexmedetomidine 5 μg / mL |
|
| Dexmedetomidine 10 | Active Comparator | Oxycodone 1 mg / mL + Dexmedetomidine 10 μg / mL |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in opioid consumption (mg) postoperatively | Change from baseline opioid consumption (mg) postoperatively at 24 hours | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change in numerical rating scale (NRS 0-10) | Number of patients with numerical rating scale value under 3 | 72 hours |
| Number of Participants with Adverse Events as a Measure of Safety and Tolerability |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Teijo I Saari, MD, PhD | Dept. Anaesthesiology and Intensive Care, University Of Turku | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Perioperative Services, Intensive Care and Pain Therapy, Turku University Hospital | Turku | 20521 | Finland |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D010098 | Oxycodone |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Oxycodone | Drug |
|
|
Efficacy of dexmedetomidine as an adjuvant in postoperative analgesia with oxycodone after spinal surgery
| 72 hours |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D003061 |
| Codeine |
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |