Prospective Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption

Prospective Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Absorption During Functional Endoscopic or Turbinate Reduction Surgery or Adenoidectomy

This proposed study will assess the hemodynamic effects and measure the systemic absorption of topically applied oxymetazoline in patients undergoing functional endoscopic sinus surgery, turbinate surgery, or adenoidectomy. These patients will be receiving oxymetazoline as standard of care during the surgery.

Inclusion Criteria:

• Patients that are scheduled for:

  1. Functional endoscopic sinus surgery
  2. Turbinate reduction (with or without tonsillectomy and/or adenoidectomy)
  3. Adenoidectomy

Exclusion Criteria:

• Been treated with oral decongestants or antihistamines within 24 hours of surgery
• Are taking anticoagulants
• Have a history of nasal trauma
• Have a history of epistaxis
• Have a history of hypertension or cardiac disease
• Allergy to oxymetazoline