Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| MR/K025090/1 | Other Grant/Funding Number | UK Medical Research Council | |
| CRN18120 | Registry Identifier | UK Clinical Research Network | |
| UOLE0482 | Other Identifier | University of Leicester (Sponsor ID) |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| University of Glasgow | OTHER |
| National Institute for Health Research, United Kingdom | OTHER_GOV |
| National Health Service, United Kingdom | OTHER_GOV |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Research has shown that reducing the time spent sitting can reduce the risk of many diseases, such as diabetes and heart disease, and improve health. It is estimated that many older adults typically spend 70% of their waking day sitting, but little is known about whether reducing sitting promotes health and well-being in this age group. The aim of this research is to investigate the health effects of reducing sitting time by replacing it with short periods of standing or walking in adults over the age of 65.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sitting | Experimental | Participants will remain sitting throughout the test period whilst undertaking typical sedentary behaviours such as watching TV, using a computer, reading and writing. Walking and standing will be restricted. |
|
| Standing | Experimental | Participants will be asked to break their sitting time by standing for five minutes every 30 minutes. Participants will be asked to stand in the same position with no further instructions provided. In total, individuals will accumulate 12 bouts (60 minutes) of standing throughout the test period. |
|
| Walking | Experimental | The walking condition will be identical to standing, but the breaks in sitting time will be punctuated with five minute bouts of self-paced walking rather than standing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sitting | Behavioral |
| ||
| Standing |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin area under the curve | Samples will be batched and analysed at the end of the study within a certified research laboratory at the Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow. Samples collected at the Leicester Diabetes Centre will be sent by courier in specialist containers and packed with dry ice. | 3 experimental intervention study visits over an estimated period of 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose area under the curve | 3 experimental intervention study visits over an estimated period of 1 month | |
| Triglyceride area under the curve | 3 experimental intervention study visits over an estimated period of 1 month |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Thomas Yates | University of Leicester | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Avenue | Glasgow | G12 8TA | United Kingdom | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30403772 | Derived | Yates T, Edwardson CL, Celis-Morales C, Biddle SJH, Bodicoat D, Davies MJ, Esliger D, Henson J, Kazi A, Khunti K, Sattar N, Sinclair AJ, Rowlands A, Velayudhan L, Zaccardi F, Gill JMR. Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):139-146. doi: 10.1093/gerona/gly252. |
| Label | URL |
|---|---|
| NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D000077708 | Sitting Position |
| D000078783 | Standing Position |
| D016138 | Walking |
| ID | Term |
|---|---|
| D011187 | Posture |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D008124 | Locomotion |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Walking | Behavioral |
|
| 1H NMR Metabolomics spectroscopy | Hydrogen-1 Nuclear Magnetic Resonance assessment undertaken on blood samples collected throughout experimental intervention days | 3 experimental intervention study visits over an estimated period of 1 month |
| Blood pressure | 3 experimental intervention study visits over an estimated period of 1 month |
| Felt Arousal Scale (0-5) | Positive affect and mood measured using the 6-point Likert Felt Arousal scale (0 = "low arousal" to 5 = "high arousal") that will be used to assess arousal. | 3 experimental intervention study visits over an estimated period of 1 month |
| Feeling Scale (-5 to +5) | Positive affect and mood measured using the 11-point Likert Feeling Scale (-5 = "very bad" to +5 = "very good") will be used to assess affective valence. | 3 experimental intervention study visits over an estimated period of 1 month |
| Semantic Verbal Fluency Test (number of items) | The Semantic Verbal Fluency Test assesses semantic memory and language, and participants will be asked to name as many items as they can that belong to a particular category. The categories selected for each of the experimental days will be clothing and animals. | 3 experimental intervention study visits over an estimated period of 1 month |
| Hopkins Verbal Learning Test (number of words recalled) | The Hopkins Verbal Learning Test assesses verbal learning and working memory and requires immediate and delayed recall of a series of 12 words over three learning trials. Participants will be requested to undertake the delayed recall component at the end of the first set of cognitive function tests and during the second set of cognitive function tests on experimental intervention days. | 3 experimental intervention study visits over an estimated period of 1 month |
| Trail Making Tests A (time to complete) | The Trail Making Tests A assesses cognitive flexibility and requires connecting randomly located numbers in numerical order (e.g. 1,2,3,4). | 3 experimental intervention study visits over an estimated period of 1 month |
| Trail Making Tests B (time to complete) | The Trail Making Tests B assesses cognitive flexibility and requires connecting randomly located numbers and letters in numerical and alphabetical order alternately (e.g. 1,A,2,B,3,C). | 3 experimental intervention study visits over an estimated period of 1 month |
| Rapid Visual Information Processing Test (number of sequences detected and errors) | The Rapid Visual Information Processing Test assesses sustained visual attention using numbers and requires both selective attention and working memory. This test displays a number on screen that changes between odd and even digits and individuals must detect target sequences of three odd or three even consecutive digits. | 3 experimental intervention study visits over an estimated period of 1 month |
| Karolinska Sleepiness Scale (1-9) | Sleep quality measured using the 9-point Likert Karolinska Sleepiness Scale (1= "very alert" to 9= "very sleepy, fighting sleep, an effort to keep awake") based on a self-reported subjective assessment of the participant's level of drowsiness at the time. | 3 experimental intervention study visits over an estimated period of 1 month |
| Leicester Diabetes Centre, Diabetes Research Unit, University of Leicester, Leicester General Hospital |
| Leicester |
| LE5 4PW |
| United Kingdom |
| Leicester Diabetes Centre | View source |
| D009068 | Movement |
| D015444 | Exercise |
| D009043 | Motor Activity |