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The purpose of this study is to exploratively evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in patients with schizophrenia who experience persistent auditory verbal hallucinations after adequate antipsychotics therapy for over three months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS | Experimental | Patients with schizophrenia to receive tDCS treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Device | 2mA direct current, 20 minutes per session, 2 sessions per day with at least 3hours interval between sessions, a total of 10 tDCS sessions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Auditory hallucination change by changes in The Psychotic Symptom Rating Scales (PSYRATs) Auditory hallucinations subscale score | Auditory hallucination change by changes in the auditory hallucinations subscale from the Psychotic Symptom Rating Scales | approximately 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Electroencephalography - resting |
| approximately 2 weeks |
| Electroencephalography - P300 peak |
|
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jun Soo Kwon, MD, PhD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D006212 | Hallucinations |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| approximately 2 weeks |
| Electroencephalography - P300 source |
| approximately 2 weeks |
| Electroencephalography - P50 |
| approximately 2 weeks |
| Electroencephalography - ERN (error-related negativity) peak |
| approximately 2 weeks |
| Electroencephalography - ERN (error-related negativity) source |
| approximately 2 weeks |
| Electroencephalography - ERN (error-related negativity) frequency activity |
| approximately 2 weeks |
| Brain Magnetic Resonance Image (MRI) - T1 Image grey matter thickness | change in grey matter thickness | approximately 2 weeks |
| Brain Magnetic Resonance Image (MRI) - T1 Image grey matter volume | change in grey matter volume | approximately 2 weeks |
| Brain MRI - functional MRI | change in Pearson's correlation coefficient of BOLD signals | approximately 2 weeks |
| Brain MRI - Diffusion Tensor Image (DTI) functional anisotropy | change in fractional anisotropy | approximately 2 weeks |
| Brain MRI - Diffusion Tensor Image (DTI) mean diffusivity | change in mean diffusivity | approximately 2 weeks |
| Brain MRI - Diffusion Tensor Image (DTI) radial diffusivity | change in radial diffusivity | approximately 2 weeks |
| Brain MRI - Diffusion Tensor Image (DTI) axial diffusivity | change in axial diffusivity | approximately 2 weeks |
| Brain MRI - myelin image | change in myelin imaging intensity value | approximately 2 weeks |
| Kicer values change with treatment in striatum assessed by 18F-DOPA Positron Emission Tomography (PET) | - Kicer values change with treatment in striatum | approximately 2 weeks |
| Magnetic Resonance Spectroscopy (MRS) | - N-Acetyl Aspartate, Creatin, Choline, Myoinositol, Glutamate, Glutamine, GABA metabolite concentration change with treatment | approximately 2 weeks |
| Auditory hallucination change by changes in the Auditory Hallucination Rating Scale (AHRS) score | Auditory hallucination change by changes in the Auditory Hallucination Rating Scale score | approximately 2 weeks |
| Auditory hallucination change by changes in the Korean Version of Hamilton Program for Schizophrenia Voices Questionnaire (HPSVQ) score | Auditory hallucination change by changes in the Korean Version of Hamilton Program for Schizophrenia Voices Questionnaire score | approximately 2 weeks |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |