Prevention of Severe Postpartum Hypertension

Furosemide for Prevention of Severe Postpartum Hypertension: a Randomized Controlled Trial

The purpose of this study is to determine whether postpartum administration of furosemide to women with antepartum hypertensive disorders (gestational hypertension, preeclampsia) or elevated blood pressure in the first 24 hours following delivery reduces severe postpartum hypertension.

Inclusion Criteria:

Women > 18 years of age or emancipated minors

Women undergoing vaginal or cesarean delivery at > 23 weeks gestation with:

• Antepartum diagnosis of gestational hypertension
• Antepartum diagnosis of preeclampsia
• Antepartum diagnosis of preeclampsia with severe features
• Mild hypertension (<150/100) in first 24 hours following delivery

Exclusion Criteria:

• Chronic hypertension
• Allergy to furosemide
• Pre-existing hypokalemia (serum K < 3.0 meq/L)
• Chronic kidney disease
• Serum Cr > 1.1
• Inability to obtain informed consent
• Pre-existing diuretic use
• Oliguria