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The purpose of this study is to know the distribution of HP in stomach before use of PPI, during use of PPI, and after stop of PPI.
Endoscopy and biopsy will be performed to investigate the distrubition of HP before, during, and after using PPI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Helicobacter pylori(HP) positive | Participants who are diagnosed with Helicobacter Pylori infection through ESD(endoscopic submucosal dissection) will be treated with PPI (proton pump inhibitor). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PPI (proton pump inhibitor) | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Analysis the change of Helicobacter pylori distribution according to the use of proton pump inhibitor | Change in the distribution of Helicobacter Pylori(HP) at 4 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Analysis the change of HP distribution according to the use of PPI in atrophic change of stomach | Change in the distribution of Helicobacter Pylori(HP) at 4 months. |
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Inclusion Criteria:
Exclusion Criteria:
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Sample size will be determined based on the analysis the distribution rate of HP at first 30 patients.
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| Name | Affiliation | Role |
|---|---|---|
| Ji Yong Ahn, Professor | Asan Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Asan Medical Center | Seoul | Songpa-gu | 138-736 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31067538 | Derived | Gong EJ, Kim DH, Ahn JY, Na HK, Jung KW, Lee JH, Choi KD, Song HJ, Lee GH, Jung HY, Park Y, Kim MJ. Effects of Proton Pump Inhibitor on the Distribution of Helicobacter pylori and Associated Gastritis in Patients with Gastric Atrophy. Digestion. 2020;101(3):279-286. doi: 10.1159/000499424. Epub 2019 May 8. |
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| ID | Term |
|---|---|
| D016481 | Helicobacter Infections |
| D013274 | Stomach Neoplasms |
| D005757 | Gastritis, Atrophic |
| ID | Term |
|---|---|
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D054328 | Proton Pump Inhibitors |
| D000077402 | Pantoprazole |
| D064747 | Lansoprazole |
| D064748 | Dexlansoprazole |
| D064750 | Rabeprazole |
| ID | Term |
|---|---|
| D004791 | Enzyme Inhibitors |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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endoscopic biopsy
|
|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D005756 | Gastritis |
| D005759 | Gastroenteritis |
| D053799 | 2-Pyridinylmethylsulfinylbenzimidazoles |
| D013454 | Sulfoxides |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |